Neandertal DNA sequences and the origin of modern humans

Matthias Krings; Anne Stone; Ralf W. Schmitz; Heike Krainitzki; Mark Stoneking; Svante Pääbo

doi:10.1016/S0092-8674(00)80310-4

Neandertal DNA sequences and the origin of modern humans

Matthias Krings, Anne Stone, Ralf W. Schmitz, Heike Krainitzki, Mark Stoneking, Svante Pääbo

Research output: Contribution to journal › Article › peer-review

948 Scopus citations

Abstract

DNA was extracted from file Neandertal-type specimen found in 1856 in western Germany. By sequencing clones from short overlapping PCR products, a hitherto unknown mitochondrial (mt) DNA sequence was determined. Multiple controls indicate that this sequence is endogenous to the fossil. Sequence comparisons with human mtDNA sequences, as well as phylogenetic analyses, show that the Neandertal sequence falls outside the variation of modern humans. Furthermore, the age of the common ancestor of the Neandertal and modem human mtDNAs is estimated to be four times greater than that of the common ancestor of human mtDNAs. This suggests that Neandertals went extinct without contributing mtDNA to modern humans.

Original language	English (US)
Pages (from-to)	19-30
Number of pages	12
Journal	Cell
Volume	90
Issue number	1
DOIs	https://doi.org/10.1016/S0092-8674(00)80310-4
State	Published - Jul 11 1997
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/S0092-8674(00)80310-4

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title = "Neandertal DNA sequences and the origin of modern humans",

abstract = "DNA was extracted from file Neandertal-type specimen found in 1856 in western Germany. By sequencing clones from short overlapping PCR products, a hitherto unknown mitochondrial (mt) DNA sequence was determined. Multiple controls indicate that this sequence is endogenous to the fossil. Sequence comparisons with human mtDNA sequences, as well as phylogenetic analyses, show that the Neandertal sequence falls outside the variation of modern humans. Furthermore, the age of the common ancestor of the Neandertal and modem human mtDNAs is estimated to be four times greater than that of the common ancestor of human mtDNAs. This suggests that Neandertals went extinct without contributing mtDNA to modern humans.",

author = "Matthias Krings and Anne Stone and Schmitz, {Ralf W.} and Heike Krainitzki and Mark Stoneking and Svante P{\"a}{\"a}bo",

note = "Funding Information: We are indebted to Drs. F. G. Zehnder and H.-E. Joachim (Rheinisches Landesmuseum Bonn) for permission to remove the sample; to H. L{\"u}dtke and M. Schultz for support and advice in the sampling process; to S. Meyer and K. Strimmer for help with computer analyses; to W. Schartau for oligonucleotide synthesis; to M. Beutelspacher, H. Fr{\"o}hlich, A. Greenwood, R. F. Grill, M. H{\"o}ss, T. Merritt, H. Poinar, L. Vigilant, and H. Zischler for discussions and help; to the Deutsche Forschungsgemeinschaft (Pa 452/3–1), the Boehringer Ingelheim Fonds (M. K.), and the National Science Foundation (M. S.) for financial support. R. W. S. especially thanks his late Ph.D. supervisor W. Taute (University of Cologne). ",

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AU - Krings, Matthias

AU - Stone, Anne

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AU - Stoneking, Mark

AU - Pääbo, Svante

N1 - Funding Information: We are indebted to Drs. F. G. Zehnder and H.-E. Joachim (Rheinisches Landesmuseum Bonn) for permission to remove the sample; to H. Lüdtke and M. Schultz for support and advice in the sampling process; to S. Meyer and K. Strimmer for help with computer analyses; to W. Schartau for oligonucleotide synthesis; to M. Beutelspacher, H. Fröhlich, A. Greenwood, R. F. Grill, M. Höss, T. Merritt, H. Poinar, L. Vigilant, and H. Zischler for discussions and help; to the Deutsche Forschungsgemeinschaft (Pa 452/3–1), the Boehringer Ingelheim Fonds (M. K.), and the National Science Foundation (M. S.) for financial support. R. W. S. especially thanks his late Ph.D. supervisor W. Taute (University of Cologne).

PY - 1997/7/11

Y1 - 1997/7/11

N2 - DNA was extracted from file Neandertal-type specimen found in 1856 in western Germany. By sequencing clones from short overlapping PCR products, a hitherto unknown mitochondrial (mt) DNA sequence was determined. Multiple controls indicate that this sequence is endogenous to the fossil. Sequence comparisons with human mtDNA sequences, as well as phylogenetic analyses, show that the Neandertal sequence falls outside the variation of modern humans. Furthermore, the age of the common ancestor of the Neandertal and modem human mtDNAs is estimated to be four times greater than that of the common ancestor of human mtDNAs. This suggests that Neandertals went extinct without contributing mtDNA to modern humans.

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Neandertal DNA sequences and the origin of modern humans

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