Naturally Occurring Inhibitors of Topoisomerase I Mediated DNA Relaxation

David E. Berry, Laurie MacKenzie, Elva A. Shultis, James A. Chan, Sidney M. Hecht

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Bioassay-guided fractionation of a methanol extract of Erodium stephanianum found to inhibit DNA topoisomerase I mediated DNA relaxation afforded corilagin (1) and chebulagic acid (2). The latter is the most potent inhibitor of mammalian topoisomerase I yet reported.

Original languageEnglish (US)
Pages (from-to)420-422
Number of pages3
JournalJournal of Organic Chemistry
Issue number2
StatePublished - Jan 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry


Dive into the research topics of 'Naturally Occurring Inhibitors of Topoisomerase I Mediated DNA Relaxation'. Together they form a unique fingerprint.

Cite this