Naturally Occurring Inhibitors of Topoisomerase I Mediated DNA Relaxation

David E. Berry; Laurie MacKenzie; Elva A. Shultis; James A. Chan; Sidney M. Hecht

doi:10.1021/jo00028a002

Naturally Occurring Inhibitors of Topoisomerase I Mediated DNA Relaxation

David E. Berry, Laurie MacKenzie, Elva A. Shultis, James A. Chan, Sidney M. Hecht

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50 Scopus citations

Abstract

Bioassay-guided fractionation of a methanol extract of Erodium stephanianum found to inhibit DNA topoisomerase I mediated DNA relaxation afforded corilagin (1) and chebulagic acid (2). The latter is the most potent inhibitor of mammalian topoisomerase I yet reported.

Original language	English (US)
Pages (from-to)	420-422
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	57
Issue number	2
DOIs	https://doi.org/10.1021/jo00028a002
State	Published - Jan 1 1992
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo00028a002

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@article{d03ae88ced754159b8d2df227837bf3a,

title = "Naturally Occurring Inhibitors of Topoisomerase I Mediated DNA Relaxation",

abstract = "Bioassay-guided fractionation of a methanol extract of Erodium stephanianum found to inhibit DNA topoisomerase I mediated DNA relaxation afforded corilagin (1) and chebulagic acid (2). The latter is the most potent inhibitor of mammalian topoisomerase I yet reported.",

author = "Berry, {David E.} and Laurie MacKenzie and Shultis, {Elva A.} and Chan, {James A.} and Hecht, {Sidney M.}",

year = "1992",

month = jan,

day = "1",

doi = "10.1021/jo00028a002",

language = "English (US)",

volume = "57",

pages = "420--422",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "2",

}

TY - JOUR

T1 - Naturally Occurring Inhibitors of Topoisomerase I Mediated DNA Relaxation

AU - Berry, David E.

AU - MacKenzie, Laurie

AU - Shultis, Elva A.

AU - Chan, James A.

AU - Hecht, Sidney M.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Bioassay-guided fractionation of a methanol extract of Erodium stephanianum found to inhibit DNA topoisomerase I mediated DNA relaxation afforded corilagin (1) and chebulagic acid (2). The latter is the most potent inhibitor of mammalian topoisomerase I yet reported.

AB - Bioassay-guided fractionation of a methanol extract of Erodium stephanianum found to inhibit DNA topoisomerase I mediated DNA relaxation afforded corilagin (1) and chebulagic acid (2). The latter is the most potent inhibitor of mammalian topoisomerase I yet reported.

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U2 - 10.1021/jo00028a002

DO - 10.1021/jo00028a002

M3 - Article

AN - SCOPUS:0026584028

SN - 0022-3263

VL - 57

SP - 420

EP - 422

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 2

ER -

Naturally Occurring Inhibitors of Topoisomerase I Mediated DNA Relaxation

Abstract

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