Natural selection in neoplastic progression of Barrett's esophagus

Carlo C. Maley, Brian J. Reid

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Neoplasms progress to cancer through a process of natural selection. The rate of evolution, and thus progression is determined by three parameters: mutation rate, population size of the evolving neoplastic cells, and intensity of selection or rate of clonal expansion. All three parameters are reviewed in the context of Barrett's esophagus, a pre-malignant neoplasm. Although Barrett's esophagus is an ideal model for the study of neoplastic clonal evolution, similar studies may be carried out in a wide variety of human neoplasms. Evolutionary analyses provide insights for clinical management, including rates of progression to cancer and emergence of resistance to interventions.

Original languageEnglish (US)
Pages (from-to)474-483
Number of pages10
JournalSeminars in Cancer Biology
Issue number6
StatePublished - Dec 2005
Externally publishedYes


  • Barrett's esophagus
  • Cancer
  • Evolution
  • Natural selection
  • Neoplastic progression

ASJC Scopus subject areas

  • Cancer Research


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