Nanoparticle-based sensing of glycan-lectin interactions

Zong Dai, Abdel Nasser Kawde, Yun Xiang, Jeffrey LaBelle, Jared Gerlach, Veer P. Bhavanandan, Lokesh Joshi, Joseph Wang

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


Here we present the first report on nanoparticle-based biosensing of glycan markers of diseases. The protocol relies on the competition between a nanocrystal (CdS)-tagged sugar and the target sugar for the binding sites of surface-confined lectin and monitoring the extent of competition through highly sensitive electrochemical detection of the captured nanocrystal. This development is expected to allow decentralized detection of carbohydrate moieties and lectin-carbohydrate interactions to be performed more rapidly, sensitively, inexpensively, and reliably.

Original languageEnglish (US)
Pages (from-to)10018-10019
Number of pages2
JournalJournal of the American Chemical Society
Issue number31
StatePublished - Aug 9 2006

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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