Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma

Joanna Jazowiecka-Rakus; Aleksander Sochanik; Aleksandra Rusin; Agata Hadryś; Wojciech Fidyk; Nancy Villa; Masmudur M. Rahman; Ewa Chmielik; Lina S. Franco; Grant McFadden

doi:10.1016/j.omto.2020.07.003

Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma

Joanna Jazowiecka-Rakus, Aleksander Sochanik, Aleksandra Rusin, Agata Hadryś, Wojciech Fidyk, Nancy Villa, Masmudur M. Rahman, Ewa Chmielik, Lina S. Franco, Grant McFadden

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Myxoma virus construct carrying the IL-15 gene was used to treat experimental pulmonary melanoma in mice. The construct was delivered systemically by mesenchymal stem (“Trojan horse”) cells and triggered an oncolytic effect and antitumor adaptive immune response. This led to marked regression of lesions and makes increased survival possible.

Original language	English (US)
Pages (from-to)	335-350
Number of pages	16
Journal	Molecular Therapy - Oncolytics
Volume	18
DOIs	https://doi.org/10.1016/j.omto.2020.07.003
State	Published - Sep 25 2020

Keywords

melanoma
mesenchymal stem cells
myxoma virus
oncolytic virotherapy

ASJC Scopus subject areas

Molecular Medicine
Oncology
Cancer Research
Pharmacology (medical)

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10.1016/j.omto.2020.07.003

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title = "Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma",

abstract = "Myxoma virus construct carrying the IL-15 gene was used to treat experimental pulmonary melanoma in mice. The construct was delivered systemically by mesenchymal stem (“Trojan horse”) cells and triggered an oncolytic effect and antitumor adaptive immune response. This led to marked regression of lesions and makes increased survival possible.",

keywords = "melanoma, mesenchymal stem cells, myxoma virus, oncolytic virotherapy",

author = "Joanna Jazowiecka-Rakus and Aleksander Sochanik and Aleksandra Rusin and Agata Hadry{\'s} and Wojciech Fidyk and Nancy Villa and Rahman, {Masmudur M.} and Ewa Chmielik and Franco, {Lina S.} and Grant McFadden",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = sep,

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doi = "10.1016/j.omto.2020.07.003",

language = "English (US)",

volume = "18",

pages = "335--350",

journal = "Molecular Therapy - Oncolytics",

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T1 - Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma

AU - Jazowiecka-Rakus, Joanna

AU - Sochanik, Aleksander

AU - Rusin, Aleksandra

AU - Hadryś, Agata

AU - Fidyk, Wojciech

AU - Villa, Nancy

AU - Rahman, Masmudur M.

AU - Chmielik, Ewa

AU - Franco, Lina S.

AU - McFadden, Grant

PY - 2020/9/25

Y1 - 2020/9/25

N2 - Myxoma virus construct carrying the IL-15 gene was used to treat experimental pulmonary melanoma in mice. The construct was delivered systemically by mesenchymal stem (“Trojan horse”) cells and triggered an oncolytic effect and antitumor adaptive immune response. This led to marked regression of lesions and makes increased survival possible.

AB - Myxoma virus construct carrying the IL-15 gene was used to treat experimental pulmonary melanoma in mice. The construct was delivered systemically by mesenchymal stem (“Trojan horse”) cells and triggered an oncolytic effect and antitumor adaptive immune response. This led to marked regression of lesions and makes increased survival possible.

KW - melanoma

KW - mesenchymal stem cells

KW - myxoma virus

KW - oncolytic virotherapy

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VL - 18

SP - 335

EP - 350

JO - Molecular Therapy - Oncolytics

JF - Molecular Therapy - Oncolytics

ER -

Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma

Abstract

Keywords

ASJC Scopus subject areas

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