Multi-scale modeling and simulation of field-effect biosensors

Christian Ringhofer, C. Heitzinger

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations


BioFETs (biologically sensitive field-effect transistors) are field- effect biosensors with semiconducting transducers. Their device structure is similar to a MOSFET, except that the gate structure is replaced by an aqueous solution containing the analyte. The detection mechanism is the conductance modulation of the transducer due to binding of the analyte to surface receptors. The main advantage of BioFETs, compared to currently available technology, is label-free operation. We present a quantitative analysis of BioFETs which is centered around multi-scale models. The technique for solving the multi-scale problem used here is the derivation of interface conditions for the Poisson equation that include the effects of the quasi-periodic biofunctionalized boundary layer. The multi- scale model enables self-consistent simulation and can be used with any charge transport model. Hence it provides the foundation for understanding the physics of the sensors by continuum models.

Original languageEnglish (US)
Title of host publicationECS Transactions - Microelectronics Technology and Devices - SBMicro 2008
Number of pages9
StatePublished - 2008
Event23rd Symposium on Microelectronics Technology and Devices, SBMicro2008 - Gramado, Brazil
Duration: Sep 1 2008Sep 4 2008

Publication series

NameECS Transactions
ISSN (Print)1938-5862
ISSN (Electronic)1938-6737


Other23rd Symposium on Microelectronics Technology and Devices, SBMicro2008

ASJC Scopus subject areas

  • General Engineering


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