Modeling the effects of fluoxetine on food-reinforced behavior

Federico Sanabria, Jazmin I. Acosta, Peter R. Killeen, Janet Neisewander, Lewis A. Bizo

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


We propose a novel method to dissociate incentive motivation from memory and motor processes in instrumental performance. Components of a multiple fixed-ratio schedule of food reinforcement were adjusted to envelop the range of response requirements that maintained lever pressing by rats. We sought to manipulate motivation for food rewards with acute administrations of various doses (0-10 mg/kg) of fluoxetine, a 5-HT reuptake inhibitor that reduces food intake. A quantitative model of fixed-ratio performance derived from Killeen's (1994) Mathematical Principles of Reinforcement (MPR) provided an adequate account of data from individual rats. Decreases in response rate resulting from fluoxetine were reflected in changes in estimates of activation, indexed by MPR parameter a; estimates of working memory capacity and lever pressing duration were not systematically affected. These results support the use of MPR parameter a to index incentive motivation using multiple fixed-ratio schedules that are adjusted to individual performance.

Original languageEnglish (US)
Pages (from-to)61-70
Number of pages10
JournalBehavioural pharmacology
Issue number1
StatePublished - Feb 2008


  • Fixed-ratio schedule of reinforcement
  • Fluoxetine
  • Food
  • Incentive motivation
  • Lever pressing
  • Models
  • Rat
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health


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