Model substrates for an RNA enzyme

William H. Mcclain, Cecilia Guerrier-Takada, Sidney Altman

Research output: Contribution to journalArticlepeer-review

239 Scopus citations


M1 RNA, the catalytic RNA subunit of Escherichia coli ribonuclease P, can cleave novel transfer RNA (tRNA) precursors that lack specific domains of the normal tRNA sequence. The smallest tRNA precursor that was cleaved efficiently retained only the domain of the amino acid acceptor stem and the T stem and loop. The importance of the 3′ terminal CCA nucleotide residues in the processing of both novel and normal tRNA precursors implies that the same enzymatic function of M1 RNA is involved.

Original languageEnglish (US)
Pages (from-to)527-530
Number of pages4
Issue number4826
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • General


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