Missorting of plasma miRNAs in aging and Alzheimer's disease

Maria Čarna, Jan S. Novotny, Neda Dragišić, Hanuš Slavik, Kateřina Sheardova, Yonas E. Geda, Martin Vyhnalek, Jan Laczo, Jakub Hort, Zixu Mao, Robert A. Rissman, Marian Hajduch, Eric B. Dammer, Gorazd B. Stokin

Research output: Contribution to journalArticlepeer-review


The observation that aging is regulated by microRNAs (miRNA) and at the same time represents the greatest risk factor for Alzheimer's disease (AD), prompted us to examine the circulating miRNA network in AD beyond aging. We here show that plasma miRNAs in aging are downregulated and predicted to be preferentially targeted to the extracellular vesicle (EV) content. In AD, miRNAs are further downregulated, display altered proportions of motifs relevant to their loading into EVs and secretion propensity, and are forecast to be found exclusively in EVs. The circulating miRNA network in AD, therefore, reflects pathological exacerbation of the aging process whereby physiological suppression of AD pathology by miRNAs becomes insufficient. (Figure presented.)

Original languageEnglish (US)
Pages (from-to)149-161
Number of pages13
JournalJournal of Neurochemistry
Issue number2
StatePublished - Apr 2023
Externally publishedYes


  • Alzheimer's disease
  • aging
  • endosomes
  • extracellular vesicles
  • miRNA
  • ncRNA
  • plasma
  • short sequence motifs

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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