Mirror image DNA nanostructures for chiral supramolecular assemblies

Chenxiang Lin, Yonggang Ke, Zhe Li, James H. Wang, Yan Liu, Hao Yan

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


L-DNA, the mirror image of natural D-DNA, can be readily self-assembled into designer discrete or periodic nanostructures. The assembly products are characterized by polyacrylamide gel electrophoresis, circular dichroism spectrum, atomic force microscope, and fluorescence microscope. We found that the use of enantiomer DNA as building material leads to the formation of DNA supramolecules with opposite chirality. Therefore, the L-DNA self-assembly is a substantial complement to the structural DNA nanotechnology. Moreover, the L-DNA architectures feature superior nuclease resistance thus are appealing for in vivo medical applications.

Original languageEnglish (US)
Pages (from-to)433-436
Number of pages4
JournalNano Letters
Issue number1
StatePublished - Jan 2009

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering


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