Abstract
This paper reports a miniaturized HPLC (HighPerformance Liquid Chromatography) column packed withnano-pore beads for flexible medical implants applications.The all-flexible-polymer column capable of integrating withmicro/nano-devices on a chip separates biological entitiesto relax stringent requirements on subsequent detectors andto enable parallel detection in a detector array. Thefabricated device has successfully separated a proteinmixture using nano-pore beads in a miniaturized column.According to HPLC analysis, the intensity ratio of large tosmall protein varies significantly, more than a factor of 300,over sample collecting time, ~ 12mins, suggesting veryhigh separation performance.
| Original language | English (US) |
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| State | Published - Nov 27 2006 |