Miniaturized Liquid Analyte Separator

Junseok Chae (Inventor)

Research output: Patent


This paper reports a miniaturized HPLC (HighPerformance Liquid Chromatography) column packed withnano-pore beads for flexible medical implants applications.The all-flexible-polymer column capable of integrating withmicro/nano-devices on a chip separates biological entitiesto relax stringent requirements on subsequent detectors andto enable parallel detection in a detector array. Thefabricated device has successfully separated a proteinmixture using nano-pore beads in a miniaturized column.According to HPLC analysis, the intensity ratio of large tosmall protein varies significantly, more than a factor of 300,over sample collecting time, ~ 12mins, suggesting veryhigh separation performance.
Original languageEnglish (US)
StatePublished - Nov 27 2006


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