MEGA6: Molecular evolutionary genetics analysis version 6.0

Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar

Research output: Contribution to journalArticlepeer-review

34531 Scopus citations


We announce the release of an advanced version of the Molecular Evolutionary Genetics Analysis (MEGA) software, which currently contains facilities for building sequence alignments, inferring phylogenetic histories, and conducting molecular evolutionary analysis. In version 6.0, MEGA now enables the inference of timetrees, as it implements the RelTime method for estimating divergence times for all branching points in a phylogeny. A new Timetree Wizard in MEGA6 facilitates this timetree inference by providing a graphical user interface (GUI) to specify the phylogeny and calibration constraints step-by-step. This version also contains enhanced algorithms to search for the optimal trees under evolutionary criteria and implements a more advanced memory management that can double the size of sequence data sets to which MEGA can be applied. Both GUI and command-line versions of MEGA6 can be downloaded from free of charge.

Original languageEnglish (US)
Pages (from-to)2725-2729
Number of pages5
JournalMolecular biology and evolution
Issue number12
StatePublished - Dec 2013


  • phylogeny
  • relaxed clocks
  • software

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics


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