Medical management of chronic cholestatic liver diseases

Andrea A. Gossard, Keith D. Lindor

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The purpose of the present review is to discuss the diagnosis and management of cholestatic liver diseases. Differential diagnoses to consider are described, including causes of extrahepatic biliary obstruction such as gallstones, strictures, extrabiliary malignancies and pancreatitis. In addition, diseases that cause intra-hepatic cholestasis such as primary biliary cirrhosis, primary sclerosing cholangitis, hepatocellular diseases and a variety of miscellaneous causes including drugs that may cause cholestasis are discussed. Primary biliary cirrhosis and primary sclerosing cholangitis are reviewed in detail, and management options are identified. The prognosis of patients with these diseases is discussed, and the Mayo Mathematical Models in Cholestatic Liver Disease for both primary biliary cirrhosis and primary sclerosing cholangitis are provided. Finally, management options for the complications of cholestasis are provided.

Original languageEnglish (US)
Pages (from-to)93D-98D
JournalCanadian Journal of Gastroenterology
Issue numberSUPPL. D
StatePublished - 2000
Externally publishedYes


  • Cholestasic liver disease
  • Primary biliary cirrhosis
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Gastroenterology


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