@inproceedings{fb18c469808245149b8a531d24c723ba,
title = "Mechanistic studies into the Raman enhancement of enediolsemiconducting nanoparticle conjugates and their use in biological applications",
abstract = "Raman scattering enhancement was observed in systems where different metal oxide semiconductors (TiO2, Fe2O3, ZrO 2 and CeO2) were modified with enediol ligands. The intensity of Raman scattering was dependent on laser frequency and correlated with the extinction coefficient of the charge-transfer complex of the enediol ligands and nanoparticles. The intensity and frequency of the Raman bands was found to depend on the chemical composition of the enediol ligand and the chemical composition (and crystallinity) of the nanoparticles. The intensity of the Raman signal depends on the number of surface binding sites, electron density of the ligands and their dipole moment. We also found that Raman scattering is observed for the bioconjugated system, where a peptide is linked to the surface of the particle through a catechol linker. These studies are important since these bioconjugates can be used to form the basis of Raman-based, in vitro and importantly in vivo biodetection, cell labeling and imaging, and nanotherapeutic strategies.",
keywords = "Biodiagnostics, Biomedical, Enediol, Nanoparticle, Nanotherapeutic, Peptide, Raman, TiO",
author = "Hurst, {Sarah J.} and Fry, {H. Christopher} and Gosztola, {David J.} and Daniel Finkelstein-Shapiro and Vladimiro Mujica and Tijana Rajh",
year = "2010",
month = oct,
day = "26",
doi = "10.1117/12.862931",
language = "English (US)",
isbn = "9780819482549",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
booktitle = "Physical Chemistry of Interfaces and Nanomaterials IX",
note = "Physical Chemistry of Interfaces and Nanomaterials IX ; Conference date: 04-08-2010 Through 05-08-2010",
}