Magnetic particle imaging with tailored iron oxide nanoparticle tracers

R. Matthew Ferguson; Amit P. Khandhar; Scott J. Kemp; Hamed Arami; Emine U. Saritas; Laura R. Croft; Justin Konkle; Patrick W. Goodwill; Aleksi Halkola; Jurgen Rahmer; Jorn Borgert; Steven M. Conolly; Kannan M. Krishnan

doi:10.1109/TMI.2014.2375065

Magnetic particle imaging with tailored iron oxide nanoparticle tracers

R. Matthew Ferguson, Amit P. Khandhar, Scott J. Kemp, Hamed Arami, Emine U. Saritas, Laura R. Croft, Justin Konkle, Patrick W. Goodwill, Aleksi Halkola, Jurgen Rahmer, Jorn Borgert, Steven M. Conolly, Kannan M. Krishnan

Research output: Contribution to journal › Article › peer-review

181 Scopus citations

Abstract

Magnetic particle imaging (MPI) shows promise for medical imaging, particularly in angiography of patients with chronic kidney disease. As the first biomedical imaging technique that truly depends on nanoscale materials properties, MPI requires highly optimized magnetic nanoparticle tracers to generate quality images. Until now, researchers have relied on tracers optimized for MRI T2^∗-weighted imaging that are sub-optimal for MPI. Here, we describe new tracers tailored to MPI's unique physics, synthesized using an organic-phase process and functionalized to ensure biocompatibility and adequate in vivo circulation time. Tailored tracers showed up to 3× greater signal-to-noise ratio and better spatial resolution than existing commercial tracers in MPI images of phantoms.

Original language	English (US)
Article number	6966754
Pages (from-to)	1077-1084
Number of pages	8
Journal	IEEE Transactions on Medical Imaging
Volume	34
Issue number	5
DOIs	https://doi.org/10.1109/TMI.2014.2375065
State	Published - May 1 2015
Externally published	Yes

Keywords

Biomedical imaging
Superparamagnetic iron oxides
magnetic particle imaging

ASJC Scopus subject areas

Software
Radiological and Ultrasound Technology
Computer Science Applications
Electrical and Electronic Engineering

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Ferguson, R. M., Khandhar, A. P., Kemp, S. J., Arami, H., Saritas, E. U., Croft, L. R., Konkle, J., Goodwill, P. W., Halkola, A., Rahmer, J., Borgert, J., Conolly, S. M., & Krishnan, K. M. (2015). Magnetic particle imaging with tailored iron oxide nanoparticle tracers. IEEE Transactions on Medical Imaging, 34(5), 1077-1084. Article 6966754. https://doi.org/10.1109/TMI.2014.2375065

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title = "Magnetic particle imaging with tailored iron oxide nanoparticle tracers",

abstract = "Magnetic particle imaging (MPI) shows promise for medical imaging, particularly in angiography of patients with chronic kidney disease. As the first biomedical imaging technique that truly depends on nanoscale materials properties, MPI requires highly optimized magnetic nanoparticle tracers to generate quality images. Until now, researchers have relied on tracers optimized for MRI T2∗-weighted imaging that are sub-optimal for MPI. Here, we describe new tracers tailored to MPI's unique physics, synthesized using an organic-phase process and functionalized to ensure biocompatibility and adequate in vivo circulation time. Tailored tracers showed up to 3× greater signal-to-noise ratio and better spatial resolution than existing commercial tracers in MPI images of phantoms.",

keywords = "Biomedical imaging, Superparamagnetic iron oxides, magnetic particle imaging",

author = "Ferguson, {R. Matthew} and Khandhar, {Amit P.} and Kemp, {Scott J.} and Hamed Arami and Saritas, {Emine U.} and Croft, {Laura R.} and Justin Konkle and Goodwill, {Patrick W.} and Aleksi Halkola and Jurgen Rahmer and Jorn Borgert and Conolly, {Steven M.} and Krishnan, {Kannan M.}",

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doi = "10.1109/TMI.2014.2375065",

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AU - Ferguson, R. Matthew

AU - Khandhar, Amit P.

AU - Kemp, Scott J.

AU - Arami, Hamed

AU - Saritas, Emine U.

AU - Croft, Laura R.

AU - Konkle, Justin

AU - Goodwill, Patrick W.

AU - Halkola, Aleksi

AU - Rahmer, Jurgen

AU - Borgert, Jorn

AU - Conolly, Steven M.

AU - Krishnan, Kannan M.

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AB - Magnetic particle imaging (MPI) shows promise for medical imaging, particularly in angiography of patients with chronic kidney disease. As the first biomedical imaging technique that truly depends on nanoscale materials properties, MPI requires highly optimized magnetic nanoparticle tracers to generate quality images. Until now, researchers have relied on tracers optimized for MRI T2∗-weighted imaging that are sub-optimal for MPI. Here, we describe new tracers tailored to MPI's unique physics, synthesized using an organic-phase process and functionalized to ensure biocompatibility and adequate in vivo circulation time. Tailored tracers showed up to 3× greater signal-to-noise ratio and better spatial resolution than existing commercial tracers in MPI images of phantoms.

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KW - Superparamagnetic iron oxides

KW - magnetic particle imaging

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Magnetic particle imaging with tailored iron oxide nanoparticle tracers

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Keywords

ASJC Scopus subject areas

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