Macrophage activating effects of new alkamides from the roots of Echinacea species

Ying Chen, Tong Fu, Tao Tao, Jinghua Yang, Yung Chang, Meihua Wang, Linda Kim, Luping Qu, John Cassady, Ric Scalzo, Xiping Wang

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Chemical investigation of the roots of Echinacea angustifolia, E. purpurea, and E. pallida yielded two new alkamides, identified by analysis of spectroscopic data and comparison with reported alkamides. The new compounds were dodeca-2Z,4E,10Z-trien-8-ynoic acid isobutylamide (1) from E. angustifolia and dodeca-2Z,4E-diene-8,10-diynoic acid isobutylamide (2) from E. purpurea and E. pallida. These two components, as well as previously identified alkamides, exerted inhibition on LPS-mediated activation of a murine macrophage line, RAW264.7. These data suggest that these alkamides may have anti-inflammatory activity. The cytotoxicity of these alkamides using MTT assays was also investigated.

Original languageEnglish (US)
Pages (from-to)773-776
Number of pages4
JournalJournal of Natural Products
Issue number5
StatePublished - May 2005

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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