Lunatic fringe null female mice are infertile due to defects in meiotic maturation

Katherine L. Hahn, Joshua Johnson, Brian J. Beres, Sheena Howard, Norma Wilson-Rawls

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


We have demonstrated that Notch genes are expressed in developing mammalian ovarian follicles. Lunatic fringe is an important regulator of Notch signaling. In this study, data are presented that demonstrate that radical fringe and lunatic fringe are expressed in the granulosa cells of developing follicles. Lunatic fringe null female mice were found to be infertile. Histological analysis of the lunatic fringe-deficient ovary demonstrated aberrant folliculogenesis. Furthermore, oocytes from these mutants did not complete meiotic maturation. This is a novel observation because this is the first report describing a meiotic defect that results from mutations in genes that are expressed in the somatic granulosa cells and not the oocytes. This represent's a new role for the Notch signaling pathway and lunatic fringe in mammalian folliculogenesis.

Original languageEnglish (US)
Pages (from-to)817-828
Number of pages12
Issue number4
StatePublished - Feb 2005


  • Fertility
  • Follicle
  • Lunatic fringe
  • Meiosis
  • Notch
  • Ovary

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology


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