Late-Season Influenza Vaccine Effectiveness Against Medically Attended Outpatient Illness, United States, December 2022–April 2023

Jessie R Chung; Philip Shirk; Manjusha Gaglani; Manohar B Mutnal; Mary Patricia Nowalk; Krissy Moehling Geffel; Stacey L House; Tara Curley; Karen J Wernli; Erika L Kiniry; Emily T Martin; Ivana A Vaughn; Vel Murugan; Efrem S Lim; Elie Saade; Kiran Faryar; Olivia L Williams; Emmanuel B Walter; Ashley M Price; John R Barnes; Juliana DaSilva; Rebecca Kondor; Sascha Ellington; Brendan Flannery

doi:10.1111/irv.13342

Late-Season Influenza Vaccine Effectiveness Against Medically Attended Outpatient Illness, United States, December 2022–April 2023

Jessie R Chung, Philip Shirk, Manjusha Gaglani, Manohar B Mutnal, Mary Patricia Nowalk, Krissy Moehling Geffel, Stacey L House, Tara Curley, Karen J Wernli, Erika L Kiniry, Emily T Martin, Ivana A Vaughn, Vel Murugan, Efrem S Lim, Elie Saade, Kiran Faryar, Olivia L Williams, Emmanuel B Walter, Ashley M Price, John R BarnesJuliana DaSilva, Rebecca Kondor, Sascha Ellington, Brendan Flannery

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The 2022–23 US influenza season peaked early in fall 2022. Methods: Late-season influenza vaccine effectiveness (VE) against outpatient, laboratory-confirmed influenza was calculated among participants of the US Influenza VE Network using a test-negative design. Results: Of 2561 participants enrolled from December 12, 2022 to April 30, 2023, 91 laboratory-confirmed influenza cases primarily had A(H1N1)pdm09 (6B.1A.5a.2a.1) or A(H3N2) (3C.2a1b.2a.2b). Overall, VE was 30% (95% confidence interval −9%, 54%); low late-season activity precluded estimation for most subgroups. Conclusions: 2022–23 late-season outpatient influenza VE was not statistically significant. Genomic characterization may improve the identification of influenza viruses that circulate postinfluenza peak.

Original language	English (US)
Article number	e13342
Journal	Influenza and other Respiratory Viruses
Volume	18
Issue number	6
DOIs	https://doi.org/10.1111/irv.13342
State	Published - Jun 2024

Keywords

influenza
vaccination
vaccine effectiveness

ASJC Scopus subject areas

Epidemiology
Pulmonary and Respiratory Medicine
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1111/irv.13342

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Chung, JR., Shirk, P., Gaglani, M., Mutnal, MB., Nowalk, MP., Moehling Geffel, K., House, SL., Curley, T., Wernli, KJ., Kiniry, EL., Martin, ET., Vaughn, IA., Murugan, V., Lim, ES., Saade, E., Faryar, K., Williams, OL., Walter, EB., Price, AM., ... Flannery, B. (2024). Late-Season Influenza Vaccine Effectiveness Against Medically Attended Outpatient Illness, United States, December 2022–April 2023. Influenza and other Respiratory Viruses, 18(6), Article e13342. https://doi.org/10.1111/irv.13342

Chung, JR, Shirk, P, Gaglani, M, Mutnal, MB, Nowalk, MP, Moehling Geffel, K, House, SL, Curley, T, Wernli, KJ, Kiniry, EL, Martin, ET, Vaughn, IA, Murugan, V , Lim, ES, Saade, E, Faryar, K, Williams, OL, Walter, EB, Price, AM, Barnes, JR, DaSilva, J, Kondor, R, Ellington, S & Flannery, B 2024, 'Late-Season Influenza Vaccine Effectiveness Against Medically Attended Outpatient Illness, United States, December 2022–April 2023', Influenza and other Respiratory Viruses, vol. 18, no. 6, e13342. https://doi.org/10.1111/irv.13342

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abstract = "Background: The 2022–23 US influenza season peaked early in fall 2022. Methods: Late-season influenza vaccine effectiveness (VE) against outpatient, laboratory-confirmed influenza was calculated among participants of the US Influenza VE Network using a test-negative design. Results: Of 2561 participants enrolled from December 12, 2022 to April 30, 2023, 91 laboratory-confirmed influenza cases primarily had A(H1N1)pdm09 (6B.1A.5a.2a.1) or A(H3N2) (3C.2a1b.2a.2b). Overall, VE was 30% (95% confidence interval −9%, 54%); low late-season activity precluded estimation for most subgroups. Conclusions: 2022–23 late-season outpatient influenza VE was not statistically significant. Genomic characterization may improve the identification of influenza viruses that circulate postinfluenza peak.",

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AU - Chung, Jessie R

AU - Shirk, Philip

AU - Gaglani, Manjusha

AU - Mutnal, Manohar B

AU - Nowalk, Mary Patricia

AU - Moehling Geffel, Krissy

AU - House, Stacey L

AU - Curley, Tara

AU - Wernli, Karen J

AU - Kiniry, Erika L

AU - Martin, Emily T

AU - Vaughn, Ivana A

AU - Murugan, Vel

AU - Lim, Efrem S

AU - Saade, Elie

AU - Faryar, Kiran

AU - Williams, Olivia L

AU - Walter, Emmanuel B

AU - Price, Ashley M

AU - Barnes, John R

AU - DaSilva, Juliana

AU - Kondor, Rebecca

AU - Ellington, Sascha

AU - Flannery, Brendan

PY - 2024/6

Y1 - 2024/6

N2 - Background: The 2022–23 US influenza season peaked early in fall 2022. Methods: Late-season influenza vaccine effectiveness (VE) against outpatient, laboratory-confirmed influenza was calculated among participants of the US Influenza VE Network using a test-negative design. Results: Of 2561 participants enrolled from December 12, 2022 to April 30, 2023, 91 laboratory-confirmed influenza cases primarily had A(H1N1)pdm09 (6B.1A.5a.2a.1) or A(H3N2) (3C.2a1b.2a.2b). Overall, VE was 30% (95% confidence interval −9%, 54%); low late-season activity precluded estimation for most subgroups. Conclusions: 2022–23 late-season outpatient influenza VE was not statistically significant. Genomic characterization may improve the identification of influenza viruses that circulate postinfluenza peak.

AB - Background: The 2022–23 US influenza season peaked early in fall 2022. Methods: Late-season influenza vaccine effectiveness (VE) against outpatient, laboratory-confirmed influenza was calculated among participants of the US Influenza VE Network using a test-negative design. Results: Of 2561 participants enrolled from December 12, 2022 to April 30, 2023, 91 laboratory-confirmed influenza cases primarily had A(H1N1)pdm09 (6B.1A.5a.2a.1) or A(H3N2) (3C.2a1b.2a.2b). Overall, VE was 30% (95% confidence interval −9%, 54%); low late-season activity precluded estimation for most subgroups. Conclusions: 2022–23 late-season outpatient influenza VE was not statistically significant. Genomic characterization may improve the identification of influenza viruses that circulate postinfluenza peak.

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Late-Season Influenza Vaccine Effectiveness Against Medically Attended Outpatient Illness, United States, December 2022–April 2023

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