Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens

George Pettit, John C. Knight, Delbert L. Herald, Richard Davenport, Robin Pettit, Bruce E. Tucker, Jean M. Schmidt

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI50 μg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).

Original languageEnglish (US)
Pages (from-to)1793-1797
Number of pages5
JournalJournal of Natural Products
Issue number12
StatePublished - Dec 1 2002

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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