Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata

Brad K. Carte; Charles DeBrosse; Drake Eggleston; Mark Hemling; Mary Mentzer; Benjamin Poehland; Nelson Troupe; John W. Westley; Sidney M. Hecht

doi:10.1016/S0040-4020(01)88369-1

Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata

Brad K. Carte, Charles DeBrosse, Drake Eggleston, Mark Hemling, Mary Mentzer, Benjamin Poehland, Nelson Troupe, John W. Westley, Sidney M. Hecht

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

A biosynthetic precursor 4 of the antitumor alkaloid camptothecin (1) has been isolated from alkaloid enriched extracts of Camptotheca acuminata. The structure of 4, which was determined both in the solid state by x-ray diffraction and in solution by NMR analysis, provides strong evidence in support of the proposed biosynthetic scheme for camptothecin (1).

Original language	English (US)
Pages (from-to)	2747-2760
Number of pages	14
Journal	Tetrahedron
Volume	46
Issue number	8
DOIs	https://doi.org/10.1016/S0040-4020(01)88369-1
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4020(01)88369-1

Cite this

@article{0ddfc0acab8d423991aa60dc7fcc5f3a,

title = "Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata",

abstract = "A biosynthetic precursor 4 of the antitumor alkaloid camptothecin (1) has been isolated from alkaloid enriched extracts of Camptotheca acuminata. The structure of 4, which was determined both in the solid state by x-ray diffraction and in solution by NMR analysis, provides strong evidence in support of the proposed biosynthetic scheme for camptothecin (1).",

author = "Carte, {Brad K.} and Charles DeBrosse and Drake Eggleston and Mark Hemling and Mary Mentzer and Benjamin Poehland and Nelson Troupe and Westley, {John W.} and Hecht, {Sidney M.}",

year = "1990",

doi = "10.1016/S0040-4020(01)88369-1",

language = "English (US)",

volume = "46",

pages = "2747--2760",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Limited",

number = "8",

}

TY - JOUR

T1 - Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata

AU - Carte, Brad K.

AU - DeBrosse, Charles

AU - Eggleston, Drake

AU - Hemling, Mark

AU - Mentzer, Mary

AU - Poehland, Benjamin

AU - Troupe, Nelson

AU - Westley, John W.

AU - Hecht, Sidney M.

PY - 1990

Y1 - 1990

N2 - A biosynthetic precursor 4 of the antitumor alkaloid camptothecin (1) has been isolated from alkaloid enriched extracts of Camptotheca acuminata. The structure of 4, which was determined both in the solid state by x-ray diffraction and in solution by NMR analysis, provides strong evidence in support of the proposed biosynthetic scheme for camptothecin (1).

AB - A biosynthetic precursor 4 of the antitumor alkaloid camptothecin (1) has been isolated from alkaloid enriched extracts of Camptotheca acuminata. The structure of 4, which was determined both in the solid state by x-ray diffraction and in solution by NMR analysis, provides strong evidence in support of the proposed biosynthetic scheme for camptothecin (1).

UR - http://www.scopus.com/inward/record.url?scp=0025237414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025237414&partnerID=8YFLogxK

U2 - 10.1016/S0040-4020(01)88369-1

DO - 10.1016/S0040-4020(01)88369-1

M3 - Article

AN - SCOPUS:0025237414

SN - 0040-4020

VL - 46

SP - 2747

EP - 2760

JO - Tetrahedron

JF - Tetrahedron

IS - 8

ER -

Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this