Involvement of the PKC family in regulation of early development

Madhavi Kalive, James J. Faust, Brian A. Koeneman, David Capco

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


Protein kinaseC(PKC) isotypes have been implicated in a number of key steps during gametogenesis, fertilization, and early development. The 11-member family of PKC isotypes, many with different cofactor requirements for activation, can provide for differential activation of the specific kinases. In addition the enrichment of particular PKC isotypes to unique locations within gametes, zygotes, and early embryos likely promotes specific substrate interactions. Evidence exists to indicate involvement of PKC isotypes during sperm capacitation and the acrosome reaction, during resumption of meiosis in the oocytes, regulating the spindle organization in meiosis I and II, at fertilization, in the pronuclei, in the mitotically dividing blastomeres of the embryo, and at the plasma membranes of blastomeres at the time of embryonic compaction. Evidence also exists for crosstalk with other signaling pathways and one or more isotypes of PKC appear to be active at each major developmental transition.

Original languageEnglish (US)
Pages (from-to)95-104
Number of pages10
JournalMolecular reproduction and development
Issue number2
StatePublished - Feb 2010

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology


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