Interindividual variability and intra-individual reproducibility of glycemic index values for commercial white bread

Sonia Vega-López, Lynne M. Ausman, John L. Griffith, Alice H. Lichtenstein

Research output: Contribution to journalArticlepeer-review

116 Scopus citations


OBJECTIVE - We sought to assess the intra- and interindividual variability of glycemic index value determinations for white bread using glucose as the reference food. RESEARCH DESIGN AND METHODS - A total of 23 healthy adults (aged 20-70 years) completed up to three sets of two visits per set. Each pair of visits assessed the glycemic response to 50 g available carbohydrates from commercial white bread and glucose, administered in random order. Glycemic index values were calculated by dividing the 2-h incremental area under the serum glucose response curve after each commercial white bread challenge by the mean area under the curve (AUC) for glucose. RESULTS - The mean ± SE ratio of the AUC after white bread intake by the AUC after glucose intake for the first set of determinations was 78 ± 15 (n = 23; coefficient of variation [CV] 94%). When using glycemic index values calculated with the subset of participants who completed three sets of tests (n = 14), glycemic index values for each of the three sets of determinations were 78 ± 10, 60 ± 5, and 75 ± 10, respectively. CVs were 50, 28, and 50%, respectively. The mean glycemic index value of these three sets was 71 ± 6, with a CV of 30%. When an ANOVA approach was applied to these data, the interindividual CV was 17.8%, and the intra-individual variation was 42.8%. CONCLUSIONS - These data suggest that in response to a challenge of white bread relative to glucose, within-individual variability is a greater contributor to overall variability than among-individual variability. Further understanding of all the sources of variability would be helpful in better defining the utility of glycemic index values.

Original languageEnglish (US)
Pages (from-to)1412-1417
Number of pages6
JournalDiabetes Care
Issue number6
StatePublished - May 2007
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing


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