Interaction of serum antibodies from breast cancer patients with synthetic peptides

S. V. Podlesnykh; E. A. Kolosova; D. N. Shcherbakov; A. A. Shaidurov; D. S. Anisimov; M. A. Ryazanov; Stephen Johnston; Ya N. Shoikhet; V. D. Petrova; A. F. Lazarev; Andrei Chapoval

doi:10.1007/s10517-016-3519-7

Interaction of serum antibodies from breast cancer patients with synthetic peptides

S. V. Podlesnykh, E. A. Kolosova, D. N. Shcherbakov, A. A. Shaidurov, D. S. Anisimov, M. A. Ryazanov, Stephen Johnston, Ya N. Shoikhet, V. D. Petrova, A. F. Lazarev, Andrei Chapoval

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The blood serum of tumor patients contains antibodies recognizing tumor-associated antigens and other molecular products of tumor growth. We studied the interaction of blood antibodies from breast cancer patients with synthetic peptides that were applied on the microchip surface. The serum from healthy volunteers and breast cancer patients was shown to contain antibodies that interact with various peptides. Statistically signifi cant between-group differences were observed in the level of binding with 122 informative peptides (0.01% of the total number of peptides on a microchip). Analysis of antibodies that interact with the peptide panel holds much promise for the diagnostics of breast cancer.

Original language	English (US)
Pages (from-to)	816-820
Number of pages	5
Journal	Bulletin of Experimental Biology and Medicine
Volume	161
Issue number	6
DOIs	https://doi.org/10.1007/s10517-016-3519-7
State	Published - Oct 1 2016

Keywords

Antibodies
Breast cancer
Epitopes
Mimotopes
Peptides microchips

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/s10517-016-3519-7

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Podlesnykh, S. V., Kolosova, E. A., Shcherbakov, D. N., Shaidurov, A. A., Anisimov, D. S., Ryazanov, M. A., Johnston, S., Shoikhet, Y. N., Petrova, V. D., Lazarev, A. F., & Chapoval, A. (2016). Interaction of serum antibodies from breast cancer patients with synthetic peptides. Bulletin of Experimental Biology and Medicine, 161(6), 816-820. https://doi.org/10.1007/s10517-016-3519-7

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abstract = "The blood serum of tumor patients contains antibodies recognizing tumor-associated antigens and other molecular products of tumor growth. We studied the interaction of blood antibodies from breast cancer patients with synthetic peptides that were applied on the microchip surface. The serum from healthy volunteers and breast cancer patients was shown to contain antibodies that interact with various peptides. Statistically signifi cant between-group differences were observed in the level of binding with 122 informative peptides (0.01% of the total number of peptides on a microchip). Analysis of antibodies that interact with the peptide panel holds much promise for the diagnostics of breast cancer.",

keywords = "Antibodies, Breast cancer, Epitopes, Mimotopes, Peptides microchips",

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AU - Podlesnykh, S. V.

AU - Kolosova, E. A.

AU - Shcherbakov, D. N.

AU - Shaidurov, A. A.

AU - Anisimov, D. S.

AU - Ryazanov, M. A.

AU - Johnston, Stephen

AU - Shoikhet, Ya N.

AU - Petrova, V. D.

AU - Lazarev, A. F.

AU - Chapoval, Andrei

PY - 2016/10/1

Y1 - 2016/10/1

N2 - The blood serum of tumor patients contains antibodies recognizing tumor-associated antigens and other molecular products of tumor growth. We studied the interaction of blood antibodies from breast cancer patients with synthetic peptides that were applied on the microchip surface. The serum from healthy volunteers and breast cancer patients was shown to contain antibodies that interact with various peptides. Statistically signifi cant between-group differences were observed in the level of binding with 122 informative peptides (0.01% of the total number of peptides on a microchip). Analysis of antibodies that interact with the peptide panel holds much promise for the diagnostics of breast cancer.

AB - The blood serum of tumor patients contains antibodies recognizing tumor-associated antigens and other molecular products of tumor growth. We studied the interaction of blood antibodies from breast cancer patients with synthetic peptides that were applied on the microchip surface. The serum from healthy volunteers and breast cancer patients was shown to contain antibodies that interact with various peptides. Statistically signifi cant between-group differences were observed in the level of binding with 122 informative peptides (0.01% of the total number of peptides on a microchip). Analysis of antibodies that interact with the peptide panel holds much promise for the diagnostics of breast cancer.

KW - Antibodies

KW - Breast cancer

KW - Epitopes

KW - Mimotopes

KW - Peptides microchips

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Interaction of serum antibodies from breast cancer patients with synthetic peptides

Abstract

Keywords

ASJC Scopus subject areas

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