Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: Hurdles, achievements, and future outlook

Graham Van Aggelen, Gerald T. Ankley, William S. Baldwin, Daniel W. Bearden, William H. Benson, J. Kevin Chipman, Tim W. Collette, John A. Craft, Nancy D. Denslow, Michael R. Embry, Francesco Falciani, Stephen G. George, Caren C. Helbing, Paul F. Hoekstra, Taisen Iguchi, Yoshi Kagami, Ioanna Katsiadaki, Peter Kille, Li Liu, Peter G. LordTerry McIntyre, Anne O'Neill, Heather Osachoff, Ed J. Perkins, Eduarda M. Santos, Rachel C. Skirrow, Jason R. Snape, Charles R. Tyler, Don Versteeg, Mark R. Viant, David C. Volz, Tim D. Williams, Lorraine Yu

Research output: Contribution to journalComment/debatepeer-review

129 Scopus citations


Background: In this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by the U.K. Natural Environment Research Council (Fish Toxicogenomics-Moving into Regulation and Monitoring, held 21-23 April 2008 at the Pacific Environmental Science Centre, Vancouver, BC, Canada). Objectives: The consortium from government agencies, academia, and industry addressed three topics: progress in ecotoxicogenomics, regulatory perspectives on roadblocks for practical implementation of toxicogenomics into risk assessment, and dealing with variability in data sets. Discussion: Participants noted that examples of successful application of omic technologies have been identified, but critical studies are needed to relate molecular changes to ecological adverse outcome. Participants made recommendations for the management of technical and biological variation. They also stressed the need for enhanced interdisciplinary training and communication as well as considerable investment into the generation and curation of appropriate reference omic data. Conclusions: The participants concluded that, although there are hurdles to pass on the road to regulatory acceptance, omics technologies are already useful for elucidating modes of action of toxicants and can contribute to the risk assessment process as part of a weight-of-evidence approach.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalEnvironmental health perspectives
Issue number1
StatePublished - Jan 1 2010
Externally publishedYes


  • Environment
  • Environmental monitoring
  • Fish
  • Metabolomics
  • Microarray
  • Regulatory toxicology
  • Transcriptomics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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