Integrated human genome−wide maps constructed using the CEPH reference panel

Kenneth H. Buetow; James L. Weber; Susan Ludwigsen; Titia Scherpbier-Heddema; Geoffrey M. Duyk; Val C. Sheffield; Zhenyuan Wang; Jeffrey C. Murray

doi:10.1038/ng0494-391

Integrated human genome−wide maps constructed using the CEPH reference panel

Kenneth H. Buetow
, James L. Weber
, Susan Ludwigsen
, Titia Scherpbier-Heddema
, Geoffrey M. Duyk
, Val C. Sheffield
, Zhenyuan Wang
, Jeffrey C. Murray

Research output: Contribution to journal › Article › peer-review

218 Scopus citations

Abstract

High resolution linkage maps have proven to be invaluable tools in genetic investigations. We have assembled a collection of genetic maps constructed from primary data collected from investigators performing genotyping using the Centre Etude Polymorphism Humain (CEPH) reference pedigree panel. These maps were constructed using a rigorous, semi−automated map construction algorithm that evaluates the integrity of the maps during construction. Two classes of maps were produced: a high confidence "skeletal" set composed of 544 PCR based markers, and a more highly annotated "framework" set containing maps of 1,123 markers. Genetic map locations within the framework maps are provided for an additional 1,758 loci without statistically unique interval assignments.

Original language	English (US)
Pages (from-to)	391-393
Number of pages	3
Journal	Nature Genetics
Volume	6
Issue number	4
DOIs	https://doi.org/10.1038/ng0494-391
State	Published - Apr 1994
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1038/ng0494-391

Cite this

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abstract = "High resolution linkage maps have proven to be invaluable tools in genetic investigations. We have assembled a collection of genetic maps constructed from primary data collected from investigators performing genotyping using the Centre Etude Polymorphism Humain (CEPH) reference pedigree panel. These maps were constructed using a rigorous, semi−automated map construction algorithm that evaluates the integrity of the maps during construction. Two classes of maps were produced: a high confidence {"}skeletal{"} set composed of 544 PCR based markers, and a more highly annotated {"}framework{"} set containing maps of 1,123 markers. Genetic map locations within the framework maps are provided for an additional 1,758 loci without statistically unique interval assignments.",

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AU - Buetow, Kenneth H.

AU - Weber, James L.

AU - Ludwigsen, Susan

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AU - Duyk, Geoffrey M.

AU - Sheffield, Val C.

AU - Wang, Zhenyuan

AU - Murray, Jeffrey C.

PY - 1994/4

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AB - High resolution linkage maps have proven to be invaluable tools in genetic investigations. We have assembled a collection of genetic maps constructed from primary data collected from investigators performing genotyping using the Centre Etude Polymorphism Humain (CEPH) reference pedigree panel. These maps were constructed using a rigorous, semi−automated map construction algorithm that evaluates the integrity of the maps during construction. Two classes of maps were produced: a high confidence "skeletal" set composed of 544 PCR based markers, and a more highly annotated "framework" set containing maps of 1,123 markers. Genetic map locations within the framework maps are provided for an additional 1,758 loci without statistically unique interval assignments.

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Integrated human genome−wide maps constructed using the CEPH reference panel

Abstract

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