Abstract
The growth of B-cell lymphoma, LSCC-RP9, in culture was inhibited by spleen cells from bursa-immunized agammaglobulinemic (A-gamma) chickens. This inhibition was mediated by suppressor T-cells. The growth of transplantable LSCT-RP6 B-cell lymphoma was suppressed in A-gamma chickens, while that of the control SPCT-RP11 T-cell tumor was not affected. Furthermore, the incidence and growth of the LSCT-RP6 tumor in normal recipients were decreased when it was co-transplanted with spleen cells from bursa immunized A-gamma chickens. The results suggest that suppressor T-cells inhibit the growth of B-cell lymphoma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1347-1352 |
| Number of pages | 6 |
| Journal | Anticancer Research |
| Volume | 10 |
| Issue number | 5 A |
| State | Published - 1990 |
| Externally published | Yes |
Keywords
- B-cell
- agammaglobulinemia
- chicken
- lymphoma growth
- suppressor T-cell
ASJC Scopus subject areas
- Oncology
- Cancer Research