Inactivating Gene Expression with Antisense Modified Oligonucleotides

Sidney Altman, Carlos Angele-Martinez

Research output: Contribution to journalArticlepeer-review


Modified nucleotides, including phosphoramidates and mesyl nucleotides, are very effective in inactivating gene expression in bacteria. Gyr A is the target gene in several organisms, including Plasmodium falciparum. Antisense reactions with bacteria infecting citrus plants are promising but incomplete.

Original languageEnglish (US)
Pages (from-to)101-105
Number of pages5
JournalActa Naturae
Issue number3
StatePublished - 2021
Externally publishedYes


  • Plasmodium falciparum
  • bacteria
  • citrus plants
  • gene expression
  • modified nucleotides

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology


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