Abstract
Quercetin is a unique dietary polyphenol because it can exert biphasic dose-responses on cells depending on its concentration. Cancer preventative effects of quercetin are observed at concentrations of approximately 1-40 mMand are likely mediated by quercetin's antioxidant properties. Pro-oxidant effects are present at cellular concentrations of 40-100 mM. However, at higher concentrations, many novel pathways in addition to ROS contribute to its effects. The potent bioactivity of quercetin has led to vigorous study of this compound and revealed numerous pathways that could interact synergistically to prevent or treat cancer. The effect of intake and concentration on emerging pathways and how they may interact are discussed in this review.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 418-428 |
| Number of pages | 11 |
| Journal | Nutrition Reviews |
| Volume | 68 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2010 |
| Externally published | Yes |
Keywords
- Estrogen receptor
- HSPs
- P53
- Quercetin
- ROS
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics