Hippocampal structure and human cognition: Key role of spatial processing and evidence supporting the efficiency hypothesis in females

Roberto Colom; Jason L. Stein; Priya Rajagopalan; Kenia Martínez; David Hermel; Yalin Wang; Juan Álvarez-Linera; Miguel Burgaleta; Ma Ángeles Quiroga; Pei Chun Shih; Paul M. Thompson

doi:10.1016/j.intell.2013.01.002

Hippocampal structure and human cognition: Key role of spatial processing and evidence supporting the efficiency hypothesis in females

Roberto Colom, Jason L. Stein, Priya Rajagopalan, Kenia Martínez, David Hermel, Yalin Wang, Juan Álvarez-Linera, Miguel Burgaleta, Ma Ángeles Quiroga, Pei Chun Shih, Paul M. Thompson

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Here we apply a method for automated segmentation of the hippocampus in 3D high-resolution structural brain MRI scans. One hundred and four healthy young adults completed twenty one tasks measuring abstract, verbal, and spatial intelligence, along with working memory, executive control, attention, and processing speed. After permutation tests corrected for multiple comparisons across vertices (p< .05), significant relationships were found for spatial intelligence, spatial working memory, and spatial executive control. Interactions with sex revealed significant relationships with the general factor of intelligence (g), along with abstract and spatial intelligence. These correlations were mainly positive for males but negative for females, which might support the efficiency hypothesis in women. Verbal intelligence, attention, and processing speed were not related to hippocampal structural differences.

Original language	English (US)
Pages (from-to)	129-140
Number of pages	12
Journal	Intelligence
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/j.intell.2013.01.002
State	Published - Mar 2013
Externally published	Yes

Keywords

Cognition
Hippocampus
Intelligence
Sex differences

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Developmental and Educational Psychology
Arts and Humanities (miscellaneous)

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10.1016/j.intell.2013.01.002

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Colom, R., Stein, J. L., Rajagopalan, P., Martínez, K., Hermel, D., Wang, Y., Álvarez-Linera, J., Burgaleta, M., Quiroga, M. Á., Shih, P. C., & Thompson, P. M. (2013). Hippocampal structure and human cognition: Key role of spatial processing and evidence supporting the efficiency hypothesis in females. Intelligence, 41(2), 129-140. https://doi.org/10.1016/j.intell.2013.01.002

Colom, R, Stein, JL, Rajagopalan, P, Martínez, K, Hermel, D, Wang, Y, Álvarez-Linera, J, Burgaleta, M, Quiroga, MÁ, Shih, PC & Thompson, PM 2013, 'Hippocampal structure and human cognition: Key role of spatial processing and evidence supporting the efficiency hypothesis in females', Intelligence, vol. 41, no. 2, pp. 129-140. https://doi.org/10.1016/j.intell.2013.01.002

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abstract = "Here we apply a method for automated segmentation of the hippocampus in 3D high-resolution structural brain MRI scans. One hundred and four healthy young adults completed twenty one tasks measuring abstract, verbal, and spatial intelligence, along with working memory, executive control, attention, and processing speed. After permutation tests corrected for multiple comparisons across vertices (p< .05), significant relationships were found for spatial intelligence, spatial working memory, and spatial executive control. Interactions with sex revealed significant relationships with the general factor of intelligence (g), along with abstract and spatial intelligence. These correlations were mainly positive for males but negative for females, which might support the efficiency hypothesis in women. Verbal intelligence, attention, and processing speed were not related to hippocampal structural differences.",

keywords = "Cognition, Hippocampus, Intelligence, Sex differences",

author = "Roberto Colom and Stein, {Jason L.} and Priya Rajagopalan and Kenia Mart{\'i}nez and David Hermel and Yalin Wang and Juan {\'A}lvarez-Linera and Miguel Burgaleta and Quiroga, {Ma {\'A}ngeles} and Shih, {Pei Chun} and Thompson, {Paul M.}",

note = "Funding Information: This work was supported by grants SEJ-2006-07890 ( Ministry of Education and Culture, Spain ), PR2008-0038 , and PSI2010-20364 ( Ministry of Science and Innovation, Spain ). Software for automated segmentation was developed at LONI (Laboratory of Neuroimaging), School of Medicine, UCLA.",

year = "2013",

month = mar,

doi = "10.1016/j.intell.2013.01.002",

language = "English (US)",

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pages = "129--140",

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AU - Colom, Roberto

AU - Stein, Jason L.

AU - Rajagopalan, Priya

AU - Martínez, Kenia

AU - Hermel, David

AU - Wang, Yalin

AU - Álvarez-Linera, Juan

AU - Burgaleta, Miguel

AU - Quiroga, Ma Ángeles

AU - Shih, Pei Chun

AU - Thompson, Paul M.

N1 - Funding Information: This work was supported by grants SEJ-2006-07890 ( Ministry of Education and Culture, Spain ), PR2008-0038 , and PSI2010-20364 ( Ministry of Science and Innovation, Spain ). Software for automated segmentation was developed at LONI (Laboratory of Neuroimaging), School of Medicine, UCLA.

PY - 2013/3

Y1 - 2013/3

N2 - Here we apply a method for automated segmentation of the hippocampus in 3D high-resolution structural brain MRI scans. One hundred and four healthy young adults completed twenty one tasks measuring abstract, verbal, and spatial intelligence, along with working memory, executive control, attention, and processing speed. After permutation tests corrected for multiple comparisons across vertices (p< .05), significant relationships were found for spatial intelligence, spatial working memory, and spatial executive control. Interactions with sex revealed significant relationships with the general factor of intelligence (g), along with abstract and spatial intelligence. These correlations were mainly positive for males but negative for females, which might support the efficiency hypothesis in women. Verbal intelligence, attention, and processing speed were not related to hippocampal structural differences.

AB - Here we apply a method for automated segmentation of the hippocampus in 3D high-resolution structural brain MRI scans. One hundred and four healthy young adults completed twenty one tasks measuring abstract, verbal, and spatial intelligence, along with working memory, executive control, attention, and processing speed. After permutation tests corrected for multiple comparisons across vertices (p< .05), significant relationships were found for spatial intelligence, spatial working memory, and spatial executive control. Interactions with sex revealed significant relationships with the general factor of intelligence (g), along with abstract and spatial intelligence. These correlations were mainly positive for males but negative for females, which might support the efficiency hypothesis in women. Verbal intelligence, attention, and processing speed were not related to hippocampal structural differences.

KW - Cognition

KW - Hippocampus

KW - Intelligence

KW - Sex differences

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Hippocampal structure and human cognition: Key role of spatial processing and evidence supporting the efficiency hypothesis in females

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