High-field 1h-nmr spectral analysis of some cucurbitacins

Xinde Fang, Chun Tao Che, A. Douglas Kinghorn, Norman R. Farnsworth, Charles H. Phoebe, Benjamin Yellin, Sidney M. Hecht

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


1H-nmr spectra of the natural products cucurbitacins A, B, C, D, E, F, I, L, 23, 24-dihydrocucurbitacin F, and hexanorcucurbitacin F, as well as three acetylated derivatives, were measured at 360 MHz in pyridine-d5. Chemical shifts and coupling constants were tabulated. In addition to all of the ring and side-chain protons, it was possible to assign several of the hydroxy group signals of these compounds. These compiled data should be useful for the structure determination of new compounds in this series.

Original languageEnglish (US)
Pages (from-to)429-434
Number of pages6
JournalJournal of Natural Products
Issue number3
StatePublished - May 1985
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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