Genetically modified rodent models: A new generation of translational cognitive science

Salvatore Oddo; Masashi Kitazawa

doi:10.1007/978-1-4939-2159-1_9

Genetically modified rodent models: A new generation of translational cognitive science

Salvatore Oddo, Masashi Kitazawa

Research output: Contribution to journal › Article › peer-review

Abstract

The brain is the key organ that differentiates humans from each other and from other animals; it stores personal experiences and knowledge in the form of memories, integrates all external information, and controls fundamental functions for survival. The underlying molecular mechanisms of learning and memory, and maintaining such high plasticity and flexibility in the brain, have remained long-lasting mysteries in the field of neuroscience. This chapter primarily focuses on the role of neurons and signal transduction pathways within the neuronal cells in learning and memory, and details the procedures used for generating genetically modified rodents. Also discussed is the application of knockout and knock-in models to understand the underlying molecular mechanisms of learning and memory, as well as the advantages and limitations of their use.

Original language	English (US)
Pages (from-to)	259-283
Number of pages	25
Journal	Neuromethods
Volume	94
DOIs	https://doi.org/10.1007/978-1-4939-2159-1_9
State	Published - Jan 1 2015
Externally published	Yes

Keywords

Animal model
Behavior
Brain
Gene modify cation
Genetic
Knock-in
Knockout
Learning
Mutation
Pathology
Signal transduction
Transgenic

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)
Psychiatry and Mental health

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10.1007/978-1-4939-2159-1_9

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abstract = "The brain is the key organ that differentiates humans from each other and from other animals; it stores personal experiences and knowledge in the form of memories, integrates all external information, and controls fundamental functions for survival. The underlying molecular mechanisms of learning and memory, and maintaining such high plasticity and flexibility in the brain, have remained long-lasting mysteries in the field of neuroscience. This chapter primarily focuses on the role of neurons and signal transduction pathways within the neuronal cells in learning and memory, and details the procedures used for generating genetically modified rodents. Also discussed is the application of knockout and knock-in models to understand the underlying molecular mechanisms of learning and memory, as well as the advantages and limitations of their use.",

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AU - Kitazawa, Masashi

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KW - Brain

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KW - Learning

KW - Mutation

KW - Pathology

KW - Signal transduction

KW - Transgenic

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Genetically modified rodent models: A new generation of translational cognitive science

Abstract

Keywords

ASJC Scopus subject areas

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