TY - JOUR
T1 - Functional horizontal gene transfer from bacteria to eukaryotes
AU - Husnik, Filip
AU - McCutcheon, John P.
N1 - Funding Information:
F.H. was supported by the Fulbright Commission and a fellowship from the European Molecular Biology Organization (EMBO; ALTF 1260–2016) while writing this Review. J.P.M. was supported by grants from the US National Science Foundation (IOS-1256680 and IOS-1553529), the US National Aeronautics and Space Administration (NASA) Astrobiology Institute (NNA15BB04A) and the Gordon and Betty Moore Foundation (GBMF5602).
Publisher Copyright:
© 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Bacteria influence eukaryotic biology as parasitic, commensal or beneficial symbionts. Aside from these organismal interactions, bacteria have also been important sources of new genetic sequences through horizontal gene transfer (HGT) for eukaryotes. In this Review, we focus on gene transfers from bacteria to eukaryotes, discuss how horizontally transferred genes become functional and explore what functions are endowed upon a broad diversity of eukaryotes by genes derived from bacteria. We classify HGT events into two broad types: those that maintain pre-existing functions and those that provide the recipient with new functionality, including altered host nutrition, protection and adaptation to extreme environments.
AB - Bacteria influence eukaryotic biology as parasitic, commensal or beneficial symbionts. Aside from these organismal interactions, bacteria have also been important sources of new genetic sequences through horizontal gene transfer (HGT) for eukaryotes. In this Review, we focus on gene transfers from bacteria to eukaryotes, discuss how horizontally transferred genes become functional and explore what functions are endowed upon a broad diversity of eukaryotes by genes derived from bacteria. We classify HGT events into two broad types: those that maintain pre-existing functions and those that provide the recipient with new functionality, including altered host nutrition, protection and adaptation to extreme environments.
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U2 - 10.1038/nrmicro.2017.137
DO - 10.1038/nrmicro.2017.137
M3 - Review article
C2 - 29176581
AN - SCOPUS:85043706978
SN - 1740-1526
VL - 16
SP - 67
EP - 79
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
IS - 2
ER -