Fathead minnow steroidogenesis: In silico analyses reveals tradeoffs between nominal target efficacy and robustness to cross-talk

Keyphrases

• Testosterone 100%
• Luteinizing Hormone 100%
• Simulation Study 100%
• Microarray Data 100%
• Estradiol 100%
• In Silico Analysis 100%
• Targeting Efficacy 100%
• Fathead Minnow 100%
• Steroidogenesis 100%
• Depuration 100%
• Steroid Production 100%
• Overproduction 50%
• Sensitivity Analysis 50%
• Mathematical Modeling 50%
• Proteomics Data 50%
• Genomic Data 50%
• Model Prediction 50%
• Protein Dynamics 50%
• Biological Noise 50%
• In Vitro Data 50%
• Systems Biology 50%
• G Protein 50%
• Microarray 50%
• Systems Biology Approach 50%
• Possible Sources 50%
• Signal Component 50%
• Steroid Hormones 50%
• Three-mode 50%
• Receptor Regulation 50%
• Inhibin 50%
• Transcriptional Regulation 50%
• Hypothalamus 50%
• Pituitary 50%
• Effective Network 50%
• Regulation Mode 50%
• Steroid Levels 50%
• Pimephales Promelas 50%
• Homeostatic Regulation 50%
• Organisational Platform 50%
• Receptor Downregulation 50%
• Trajectory Behavior 50%
• Steroidogenic 50%
• Aromatase Inhibitors 50%
• Ovarian Steroidogenesis 50%
• P450 Enzymes 50%
• Fadrozole 50%
• Predictive Ecotoxicology 50%
• Major Challenges 50%
• Genetic Regulation 50%
• Microarray Assay 50%
• Global Cue 50%

Biochemistry, Genetics and Molecular Biology

• Steroid Biosynthesis 100%
• Pimephales Promelas 100%
• Steroid 100%
• Hormone Receptor 40%
• Genomics 40%
• Estradiol 40%
• Testosterone 40%
• Luteinizing Hormone 40%
• Microarray Data 40%
• Protein Dynamics 20%
• Downregulation 20%
• Enzyme Induction 20%
• Receptor Upregulation 20%
• Fadrozole 20%
• Aromatase Inhibitor 20%
• G Protein 20%
• Cytochrome P450 20%
• Proteomics 20%