Evolutionary determinants of genome-wide nucleotide composition

Hongan Long, Way Sung, Sibel Kucukyildirim, Emily Williams, Samuel F. Miller, Wanfeng Guo, Caitlyn Patterson, Colin Gregory, Chloe Strauss, Casey Stone, Cécile Berne, David Kysela, William R. Shoemaker, Mario E. Muscarella, Haiwei Luo, Jay T. Lennon, Yves V. Brun, Michael Lynch

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


One of the long-standing mysteries of evolutionary genomics is the source of the wide phylogenetic diversity in genome nucleotide composition (G + C versus A + T), which must be a consequence of interspecific differences in mutation bias, the efficiency of selection for different nucleotides or a combination of the two. We demonstrate that although genomic G + C composition is strongly driven by mutation bias, it is also substantially modified by direct selection and/or as a by-product of biased gene conversion. Moreover, G + C composition at fourfold redundant sites is consistently elevated above the neutral expectation - more so than for any other class of sites.

Original languageEnglish (US)
Pages (from-to)237-240
Number of pages4
JournalNature Ecology and Evolution
Issue number2
StatePublished - Feb 1 2018

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology


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