Evidence for balancing selection at HLA

P. W. Hedrick, G. Thomson

Research output: Contribution to journalArticlepeer-review

208 Scopus citations


HLA data from the A and B loci for 22 populations were compared with the neutrality expectations from Ewens' sampling theory. In 25 of 44 cases, there was significantly less homozygosity than expected. Although a number of factors can affect homozygosity in this manner, upon close examination only symmetrical balancing selection appears to be consistent with these data.

Original languageEnglish (US)
Pages (from-to)449-456
Number of pages8
Issue number3
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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