Estimation of parameters governing the transmission dynamics of schistosomes

Z. Feng; A. Eppert; F. A. Milner; D. J. Minchella

doi:10.1016/j.aml.2004.02.002

Estimation of parameters governing the transmission dynamics of schistosomes

Z. Feng, A. Eppert, F. A. Milner, D. J. Minchella

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

The clumping parameter related to the distribution of schistosome parasites is obtained by fitting a negative binomial distribution to data collected from patients in a village in Brazil; the natural uninfected and parasite-induced snail host mortality rates are obtained from laboratory data. These values are used in a schistosomiasis model proposed earlier by the authors, and a disease transmission parameter from snails to humans is estimated. Finally, the effect of chemotherapy of humans is assessed using prevalence of morbidity as a measure of the level of schistosome infection in a human population.

Original language	English (US)
Pages (from-to)	1105-1112
Number of pages	8
Journal	Applied Mathematics Letters
Volume	17
Issue number	10
DOIs	https://doi.org/10.1016/j.aml.2004.02.002
State	Published - 2004
Externally published	Yes

Keywords

Control strategy
Mathematical model
Parameter estimation
Schistosomiasis

ASJC Scopus subject areas

Applied Mathematics

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10.1016/j.aml.2004.02.002

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title = "Estimation of parameters governing the transmission dynamics of schistosomes",

abstract = "The clumping parameter related to the distribution of schistosome parasites is obtained by fitting a negative binomial distribution to data collected from patients in a village in Brazil; the natural uninfected and parasite-induced snail host mortality rates are obtained from laboratory data. These values are used in a schistosomiasis model proposed earlier by the authors, and a disease transmission parameter from snails to humans is estimated. Finally, the effect of chemotherapy of humans is assessed using prevalence of morbidity as a measure of the level of schistosome infection in a human population.",

keywords = "Control strategy, Mathematical model, Parameter estimation, Schistosomiasis",

author = "Z. Feng and A. Eppert and Milner, {F. A.} and Minchella, {D. J.}",

note = "Funding Information: This research is partially supported by the NSF Grants DMS-9974389 and DMS-0314575.",

year = "2004",

doi = "10.1016/j.aml.2004.02.002",

language = "English (US)",

volume = "17",

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TY - JOUR

T1 - Estimation of parameters governing the transmission dynamics of schistosomes

AU - Feng, Z.

AU - Eppert, A.

AU - Milner, F. A.

AU - Minchella, D. J.

N1 - Funding Information: This research is partially supported by the NSF Grants DMS-9974389 and DMS-0314575.

PY - 2004

Y1 - 2004

N2 - The clumping parameter related to the distribution of schistosome parasites is obtained by fitting a negative binomial distribution to data collected from patients in a village in Brazil; the natural uninfected and parasite-induced snail host mortality rates are obtained from laboratory data. These values are used in a schistosomiasis model proposed earlier by the authors, and a disease transmission parameter from snails to humans is estimated. Finally, the effect of chemotherapy of humans is assessed using prevalence of morbidity as a measure of the level of schistosome infection in a human population.

AB - The clumping parameter related to the distribution of schistosome parasites is obtained by fitting a negative binomial distribution to data collected from patients in a village in Brazil; the natural uninfected and parasite-induced snail host mortality rates are obtained from laboratory data. These values are used in a schistosomiasis model proposed earlier by the authors, and a disease transmission parameter from snails to humans is estimated. Finally, the effect of chemotherapy of humans is assessed using prevalence of morbidity as a measure of the level of schistosome infection in a human population.

KW - Control strategy

KW - Mathematical model

KW - Parameter estimation

KW - Schistosomiasis

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DO - 10.1016/j.aml.2004.02.002

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VL - 17

SP - 1105

EP - 1112

JO - Applied Mathematics Letters

JF - Applied Mathematics Letters

IS - 10

ER -

Estimation of parameters governing the transmission dynamics of schistosomes

Abstract

Keywords

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