Epigenetic approaches to developmental psychopathology

H. Hill Goldsmith, I. I. Gottesman, K. S. Lemery

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


We evaluate the usefulness of 11 key epigenetic concepts from the behavior genetic research paradigm for advancing the field of developmental psychopathology. Key assumptions, empirical examples, and caveats in interpreting results are presented. We emphasize the usefulness of incorporating both dimensional (e.g., temperament trait) and categorical (e.g., diagnosis) variables, environmental measures, direct behavioral assessments, and multiple, theoretically relevant occasions of study into classic twin and family studies. We highlight contemporary techniques for identifying specific chromosomal regions associated with behavioral patterns, and the importance of considering nonmendelizing genetic influences when discerning the panorama of genetic influences on behavior.

Original languageEnglish (US)
Pages (from-to)365-387
Number of pages23
JournalDevelopment and psychopathology
Issue number2
StatePublished - Jan 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health


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