TY - JOUR
T1 - ENIGMA-Meditation
T2 - Worldwide Consortium for Neuroscientific Investigations of Meditation Practices
AU - Ganesan, Saampras
AU - Barrios, Fernando A.
AU - Batta, Ishaan
AU - Bauer, Clemens C.C.
AU - Braver, Todd S.
AU - Brewer, Judson A.
AU - Brown, Kirk Warren
AU - Cahn, Rael
AU - Cain, Joshua A.
AU - Calhoun, Vince D.
AU - Cao, Lei
AU - Chetelat, Gaël
AU - Ching, Christopher R.K.
AU - Creswell, J. David
AU - Dagnino, Paulina Clara
AU - Davanger, Svend
AU - Davidson, Richard J.
AU - Deco, Gustavo
AU - Dutcher, Janine M.
AU - Escrichs, Anira
AU - Eyler, Lisa T.
AU - Fani, Negar
AU - Farb, Norman A.S.
AU - Fialoke, Suruchi
AU - Fresco, David M.
AU - Garg, Rahul
AU - Garland, Eric L.
AU - Goldin, Philippe
AU - Hafeman, Danella M.
AU - Jahanshad, Neda
AU - Kang, Yoona
AU - Khalsa, Sahib S.
AU - Kirlic, Namik
AU - Lazar, Sara W.
AU - Lutz, Antoine
AU - McDermott, Timothy J.
AU - Pagnoni, Giuseppe
AU - Piguet, Camille
AU - Prakash, Ruchika S.
AU - Rahrig, Hadley
AU - Reggente, Nicco
AU - Saccaro, Luigi F.
AU - Sacchet, Matthew D.
AU - Siegle, Greg J.
AU - Tang, Yi Yuan
AU - Thomopoulos, Sophia I.
AU - Thompson, Paul M.
AU - Torske, Alyssa
AU - Treves, Isaac N.
AU - Tripathi, Vaibhav
AU - Tsuchiyagaito, Aki
AU - Turner, Matthew D.
AU - Vago, David R.
AU - Valk, Sofie
AU - Zeidan, Fadel
AU - Zalesky, Andrew
AU - Turner, Jessica A.
AU - King, Anthony P.
N1 - Publisher Copyright:
© 2025
PY - 2025
Y1 - 2025
N2 - Meditation is a family of ancient and contemporary contemplative mind-body practices that can modulate psychological processes, awareness, and mental states. Over the last 40 years, clinical science has manualized meditation practices and designed various meditation interventions that have shown therapeutic efficacy for disorders including depression, pain, addiction, and anxiety. Over the past decade, neuroimaging has been used to examine the neuroscientific basis of meditation practices, effects, states, and outcomes for clinical and nonclinical populations. However, the generalizability and replicability of current neuroscientific models of meditation have not yet been established, because they are largely based on small datasets entrenched with heterogeneity along several domains of meditation (e.g., practice types, meditation experience, clinical disorder targeted), experimental design, and neuroimaging methods (e.g., preprocessing, analysis, task-based, resting-state, structural magnetic resonance imaging). These limitations have precluded a nuanced and rigorous neuroscientific phenotyping of meditation practices and their potential benefits. Here, we present ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis)–Meditation, the first worldwide collaborative consortium for neuroscientific investigations of meditation practices. ENIGMA-Meditation will enable systematic meta- and mega-analyses of globally distributed neuroimaging datasets of meditation using shared, standardized neuroimaging methods and tools to improve statistical power and generalizability. Through this powerful collaborative framework, existing neuroscientific accounts of meditation practices can be extended to generate novel and rigorous neuroscientific insights that account for multidomain heterogeneity. ENIGMA-Meditation will inform neuroscientific mechanisms that underlie therapeutic action of meditation practices on psychological and cognitive attributes, thereby advancing the field of meditation and contemplative neuroscience.
AB - Meditation is a family of ancient and contemporary contemplative mind-body practices that can modulate psychological processes, awareness, and mental states. Over the last 40 years, clinical science has manualized meditation practices and designed various meditation interventions that have shown therapeutic efficacy for disorders including depression, pain, addiction, and anxiety. Over the past decade, neuroimaging has been used to examine the neuroscientific basis of meditation practices, effects, states, and outcomes for clinical and nonclinical populations. However, the generalizability and replicability of current neuroscientific models of meditation have not yet been established, because they are largely based on small datasets entrenched with heterogeneity along several domains of meditation (e.g., practice types, meditation experience, clinical disorder targeted), experimental design, and neuroimaging methods (e.g., preprocessing, analysis, task-based, resting-state, structural magnetic resonance imaging). These limitations have precluded a nuanced and rigorous neuroscientific phenotyping of meditation practices and their potential benefits. Here, we present ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis)–Meditation, the first worldwide collaborative consortium for neuroscientific investigations of meditation practices. ENIGMA-Meditation will enable systematic meta- and mega-analyses of globally distributed neuroimaging datasets of meditation using shared, standardized neuroimaging methods and tools to improve statistical power and generalizability. Through this powerful collaborative framework, existing neuroscientific accounts of meditation practices can be extended to generate novel and rigorous neuroscientific insights that account for multidomain heterogeneity. ENIGMA-Meditation will inform neuroscientific mechanisms that underlie therapeutic action of meditation practices on psychological and cognitive attributes, thereby advancing the field of meditation and contemplative neuroscience.
KW - Consortium
KW - ENIGMA
KW - Magnetic resonance imaging (MRI)
KW - Meditation
KW - Mindfulness
KW - Neuroimaging
UR - http://www.scopus.com/inward/record.url?scp=85216012206&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85216012206&partnerID=8YFLogxK
U2 - 10.1016/j.bpsc.2024.10.015
DO - 10.1016/j.bpsc.2024.10.015
M3 - Review article
C2 - 39515581
AN - SCOPUS:85216012206
SN - 2451-9022
JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
ER -