Enhancement of the Electrical Properties of DNA Molecular Wires through Incorporation of Perylenediimide DNA Base Surrogates

Kuo Yao Lin; Anthony Burke; Nolan B. King; Dimithree Kahanda; Amir Mazaheripour; Andrew Bartlett; David J. Dibble; Marc A. McWilliams; David W. Taylor; Jonah Micah Jocson; Majid Minary-Jolandan; Alon A. Gorodetsky; Jason D. Slinker

doi:10.1002/cplu.201800661

Enhancement of the Electrical Properties of DNA Molecular Wires through Incorporation of Perylenediimide DNA Base Surrogates

Kuo Yao Lin, Anthony Burke, Nolan B. King, Dimithree Kahanda, Amir Mazaheripour, Andrew Bartlett, David J. Dibble, Marc A. McWilliams, David W. Taylor, Jonah Micah Jocson, Majid Minary-Jolandan, Alon A. Gorodetsky, Jason D. Slinker

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

DNA has long been viewed as a promising material for nanoscale electronics, in part due to its well-ordered arrangement of stacked, pi-conjugated base pairs. Within this context, a number of studies have investigated how structural changes, backbone modifications, or artificial base substitutions affect the conductivity of DNA. Herein, we present a comparative study of the electrical properties of both well-matched and perylene-3,4,9,10-tetracarboxylic diimide (PTCDI)-containing DNA molecular wires that bridge nanoscale gold electrodes. By performing current-voltage measurements for such devices, we find that the incorporation of PTCDI DNA base surrogates within our macromolecular constructs leads to an approximately 6-fold enhancement in the observed current levels. Together, these findings suggest that PTCDI DNA base surrogates may enable the preparation of designer DNA-based nanoscale electronic components.

Original language	English (US)
Pages (from-to)	416-419
Number of pages	4
Journal	ChemPlusChem
Volume	84
Issue number	4
DOIs	https://doi.org/10.1002/cplu.201800661
State	Published - Apr 2019
Externally published	Yes

Keywords

PTCDI
bioelectronics
charge transport
nanoscale devices
nanotechnology

ASJC Scopus subject areas

Chemistry(all)

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10.1002/cplu.201800661

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Lin, K. Y., Burke, A., King, N. B., Kahanda, D., Mazaheripour, A., Bartlett, A., Dibble, D. J., McWilliams, M. A., Taylor, D. W., Jocson, J. M., Minary-Jolandan, M., Gorodetsky, A. A., & Slinker, J. D. (2019). Enhancement of the Electrical Properties of DNA Molecular Wires through Incorporation of Perylenediimide DNA Base Surrogates. ChemPlusChem, 84(4), 416-419. https://doi.org/10.1002/cplu.201800661

Lin, KY, Burke, A, King, NB, Kahanda, D, Mazaheripour, A, Bartlett, A, Dibble, DJ, McWilliams, MA, Taylor, DW, Jocson, JM, Minary-Jolandan, M, Gorodetsky, AA & Slinker, JD 2019, 'Enhancement of the Electrical Properties of DNA Molecular Wires through Incorporation of Perylenediimide DNA Base Surrogates', ChemPlusChem, vol. 84, no. 4, pp. 416-419. https://doi.org/10.1002/cplu.201800661

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title = "Enhancement of the Electrical Properties of DNA Molecular Wires through Incorporation of Perylenediimide DNA Base Surrogates",

abstract = "DNA has long been viewed as a promising material for nanoscale electronics, in part due to its well-ordered arrangement of stacked, pi-conjugated base pairs. Within this context, a number of studies have investigated how structural changes, backbone modifications, or artificial base substitutions affect the conductivity of DNA. Herein, we present a comparative study of the electrical properties of both well-matched and perylene-3,4,9,10-tetracarboxylic diimide (PTCDI)-containing DNA molecular wires that bridge nanoscale gold electrodes. By performing current-voltage measurements for such devices, we find that the incorporation of PTCDI DNA base surrogates within our macromolecular constructs leads to an approximately 6-fold enhancement in the observed current levels. Together, these findings suggest that PTCDI DNA base surrogates may enable the preparation of designer DNA-based nanoscale electronic components.",

keywords = "PTCDI, bioelectronics, charge transport, nanoscale devices, nanotechnology",

author = "Lin, {Kuo Yao} and Anthony Burke and King, {Nolan B.} and Dimithree Kahanda and Amir Mazaheripour and Andrew Bartlett and Dibble, {David J.} and McWilliams, {Marc A.} and Taylor, {David W.} and Jocson, {Jonah Micah} and Majid Minary-Jolandan and Gorodetsky, {Alon A.} and Slinker, {Jason D.}",

note = "Funding Information: The authors acknowledge support from the National Science Foundation (CMMI-1246762), the Air Force Office of Scientific Research (FA9550-13-1-0096), and the Office of Naval Research (N00014-16-1-2741). The authors would also like to thank Dr. Gary Frazier for programming assistance with testing software. This work was performed in part at the UTD Cleanroom Research Laboratory. Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

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doi = "10.1002/cplu.201800661",

language = "English (US)",

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AU - King, Nolan B.

AU - Kahanda, Dimithree

AU - Mazaheripour, Amir

AU - Bartlett, Andrew

AU - Dibble, David J.

AU - McWilliams, Marc A.

AU - Taylor, David W.

AU - Jocson, Jonah Micah

AU - Minary-Jolandan, Majid

AU - Gorodetsky, Alon A.

AU - Slinker, Jason D.

N1 - Funding Information: The authors acknowledge support from the National Science Foundation (CMMI-1246762), the Air Force Office of Scientific Research (FA9550-13-1-0096), and the Office of Naval Research (N00014-16-1-2741). The authors would also like to thank Dr. Gary Frazier for programming assistance with testing software. This work was performed in part at the UTD Cleanroom Research Laboratory. Publisher Copyright: © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2019/4

Y1 - 2019/4

N2 - DNA has long been viewed as a promising material for nanoscale electronics, in part due to its well-ordered arrangement of stacked, pi-conjugated base pairs. Within this context, a number of studies have investigated how structural changes, backbone modifications, or artificial base substitutions affect the conductivity of DNA. Herein, we present a comparative study of the electrical properties of both well-matched and perylene-3,4,9,10-tetracarboxylic diimide (PTCDI)-containing DNA molecular wires that bridge nanoscale gold electrodes. By performing current-voltage measurements for such devices, we find that the incorporation of PTCDI DNA base surrogates within our macromolecular constructs leads to an approximately 6-fold enhancement in the observed current levels. Together, these findings suggest that PTCDI DNA base surrogates may enable the preparation of designer DNA-based nanoscale electronic components.

AB - DNA has long been viewed as a promising material for nanoscale electronics, in part due to its well-ordered arrangement of stacked, pi-conjugated base pairs. Within this context, a number of studies have investigated how structural changes, backbone modifications, or artificial base substitutions affect the conductivity of DNA. Herein, we present a comparative study of the electrical properties of both well-matched and perylene-3,4,9,10-tetracarboxylic diimide (PTCDI)-containing DNA molecular wires that bridge nanoscale gold electrodes. By performing current-voltage measurements for such devices, we find that the incorporation of PTCDI DNA base surrogates within our macromolecular constructs leads to an approximately 6-fold enhancement in the observed current levels. Together, these findings suggest that PTCDI DNA base surrogates may enable the preparation of designer DNA-based nanoscale electronic components.

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Enhancement of the Electrical Properties of DNA Molecular Wires through Incorporation of Perylenediimide DNA Base Surrogates

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