Engineering gain-of-function mutants of a WW domain by dynamics and structural analysis

Keyphrases

• Gain-of-function mutation 100%
• WW Domain 100%
• CC16 100%
• Foldability 60%
• Binding Affinity 40%
• Local Contact 40%
• Dynamic Profile 40%
• Dynamic Base 20%
• Nature-inspired 20%
• Peptide Ligand 20%
• Protein Sequence 20%
• Classical Studies 20%
• Computational Design 20%
• Small Protein 20%
• Binding Site 20%
• Ligand Complexes 20%
• Single-point mutation 20%
• Designed Proteins 20%
• Evolutionary Selection 20%
• Peptide Binding 20%
• Protein Gain 20%
• Different Dynamics 20%
• Statistical Coupling Analysis 20%
• On-path 20%
• Folding Energy Landscapes 20%

Biochemistry, Genetics and Molecular Biology

• Dynamics 100%
• Binding Affinity 100%
• WW Domain 100%
• Point Mutation 50%
• Peptide Sequence 50%
• Binding Site 50%
• Energy Landscape 50%
• Evolution 50%