Enabling individualized therapy through nanotechnology

Jason H. Sakamoto, Anne L. van de Ven, Biana Godin, Elvin Blanco, Rita E. Serda, Alessandro Grattoni, Arturas Ziemys, Ali Bouamrani, Tony Hu, Shivakumar I. Ranganathan, Enrica De Rosa, Jonathan O. Martinez, Christine A. Smid, Rachel M. Buchanan, Sei Young Lee, Srimeenakshi Srinivasan, Matthew Landry, Anne Meyn, Ennio Tasciotti, Xuewu LiuPaolo Decuzzi, Mauro Ferrari

Research output: Contribution to journalReview articlepeer-review

172 Scopus citations


Individualized medicine is the healthcare strategy that rebukes the idiomatic dogma of 'losing sight of the forest for the trees'. We are entering a new era of healthcare where it is no longer acceptable to develop and market a drug that is effective for only 80% of the patient population. The emergence of "-omic" technologies (e.g. genomics, transcriptomics, proteomics, metabolomics) and advances in systems biology are magnifying the deficiencies of standardized therapy, which often provide little treatment latitude for accommodating patient physiologic idiosyncrasies. A personalized approach to medicine is not a novel concept. Ever since the scientific community began unraveling the mysteries of the genome, the promise of discarding generic treatment regimens in favor of patient-specific therapies became more feasible and realistic. One of the major scientific impediments of this movement towards personalized medicine has been the need for technological enablement. Nanotechnology is projected to play a critical role in patient-specific therapy; however, this transition will depend heavily upon the evolutionary development of a systems biology approach to clinical medicine based upon "-omic" technology analysis and integration. This manuscript provides a forward looking assessment of the promise of nanomedicine as it pertains to individualized medicine and establishes a technology "snapshot" of the current state of nano-based products over a vast array of clinical indications and range of patient specificity. Other issues such as market driven hurdles and regulatory compliance reform are anticipated to "self-correct" in accordance to scientific advancement and healthcare demand. These peripheral, non-scientific concerns are not addressed at length in this manuscript; however they do exist, and their impact to the paradigm shifting healthcare transformation towards individualized medicine will be critical for its success.

Original languageEnglish (US)
Pages (from-to)57-89
Number of pages33
JournalPharmacological Research
Issue number2
StatePublished - Aug 2010
Externally publishedYes


  • -Omic technologies
  • Implantable device
  • Individualized therapy
  • Nanomedicine
  • Nanoparticle
  • Nanotechnology
  • Nanovector
  • Personalized medicine
  • Regulatory process
  • Systems biology
  • Tissue engineering

ASJC Scopus subject areas

  • Pharmacology


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