Eicosanoids and the large intestine

Wade Krause; Raymond N. Dubois

doi:10.1016/S0090-6980(00)00069-1

Eicosanoids and the large intestine

Wade Krause, Raymond N. Dubois

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

During the past three decades, many studies have been conducted to determine the precise role of eicosanoids in colorectal physiology and pathophysiology. This research has increased our understanding of bioactive lipid signaling, and may contribute to the development of more effective therapeutic modalities for digestive diseases in the future. The purpose of this report is to provide a brief overview of the role of eicosanoids in the colon and rectum. This information has been organized according to both functional and disease-related categories. The role of eicosanoids in colonic secretion, motility, inflammatory bowel disease, and colorectal neoplasia will be discussed. Copyright (C) 2000 Elsevier Science Inc.

Original language	English (US)
Pages (from-to)	145-161
Number of pages	17
Journal	Prostaglandins and Other Lipid Mediators
Volume	61
Issue number	3-4
DOIs	https://doi.org/10.1016/S0090-6980(00)00069-1
State	Published - May 2000
Externally published	Yes

Keywords

Colon
Colorectal cancer
Eicosanoids
Inflammatory bowel disease
Ion transport
Secretion

ASJC Scopus subject areas

Biochemistry
Physiology
Pharmacology
Cell Biology

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10.1016/S0090-6980(00)00069-1

Cite this

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title = "Eicosanoids and the large intestine",

abstract = "During the past three decades, many studies have been conducted to determine the precise role of eicosanoids in colorectal physiology and pathophysiology. This research has increased our understanding of bioactive lipid signaling, and may contribute to the development of more effective therapeutic modalities for digestive diseases in the future. The purpose of this report is to provide a brief overview of the role of eicosanoids in the colon and rectum. This information has been organized according to both functional and disease-related categories. The role of eicosanoids in colonic secretion, motility, inflammatory bowel disease, and colorectal neoplasia will be discussed. Copyright (C) 2000 Elsevier Science Inc.",

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AU - Krause, Wade

AU - Dubois, Raymond N.

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AB - During the past three decades, many studies have been conducted to determine the precise role of eicosanoids in colorectal physiology and pathophysiology. This research has increased our understanding of bioactive lipid signaling, and may contribute to the development of more effective therapeutic modalities for digestive diseases in the future. The purpose of this report is to provide a brief overview of the role of eicosanoids in the colon and rectum. This information has been organized according to both functional and disease-related categories. The role of eicosanoids in colonic secretion, motility, inflammatory bowel disease, and colorectal neoplasia will be discussed. Copyright (C) 2000 Elsevier Science Inc.

KW - Colon

KW - Colorectal cancer

KW - Eicosanoids

KW - Inflammatory bowel disease

KW - Ion transport

KW - Secretion

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DO - 10.1016/S0090-6980(00)00069-1

M3 - Review article

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AN - SCOPUS:0034041237

SN - 0090-6980

VL - 61

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JO - Prostaglandins and Other Lipid Mediators

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IS - 3-4

ER -

Eicosanoids and the large intestine

Abstract

Keywords

ASJC Scopus subject areas

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