TY - JOUR
T1 - Effect of the injection solvent on steroid activity
AU - Deviche, P.
AU - Balthazart, J.
N1 - Funding Information:
We are indebted to Professor E. Schoffeniels for his continued interest in our research. This work was supported by a grant from the Belgian FNRS to J. Balthazart (Credits aux Chercheurs) and Grant 2.4518.80 from the FRFC to Professor E. Schof-feniels. We thank Dr. B. K. Follett (Bristol University, Department of Zoology, U.K.) for generously providing the materials for LH assay, and Dr. F. L. Moore (Oregon State University at Corvallis, Department of Zoology) and Dr. L. Delattre (Institute of Pharmacy, University of Liege) for helpful comments on an earlier version of this manuscript.
PY - 1987/2
Y1 - 1987/2
N2 - The effects of testosterone, 5α-dihydrotestosterone, and androstenedione on cloacal gland and sternotracheal muscle growth and on luteinizing hormone plasma levels were studied in Japanese quail. The steroids were given to the animals in daily intramuscular injections and were dissolved either in propylene glycol or in ethanol:saline (1:1). The three steroids had significant effects on the responses which were measured, but the magnitude of this effect was clearly related to the type of vehicle in which the steroids were dissolved. Furthermore there was a significant interaction between the effects of solvents and of steroid; for example, testosterone was much less androgenic than 5α-dihydrotestosterone when dissolved in propylene glycol, but both had similar effects when dissolved in ethanol:saline. The effects of the mode of administration of different steroids on a given physiological response should be taken into consideration.
AB - The effects of testosterone, 5α-dihydrotestosterone, and androstenedione on cloacal gland and sternotracheal muscle growth and on luteinizing hormone plasma levels were studied in Japanese quail. The steroids were given to the animals in daily intramuscular injections and were dissolved either in propylene glycol or in ethanol:saline (1:1). The three steroids had significant effects on the responses which were measured, but the magnitude of this effect was clearly related to the type of vehicle in which the steroids were dissolved. Furthermore there was a significant interaction between the effects of solvents and of steroid; for example, testosterone was much less androgenic than 5α-dihydrotestosterone when dissolved in propylene glycol, but both had similar effects when dissolved in ethanol:saline. The effects of the mode of administration of different steroids on a given physiological response should be taken into consideration.
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U2 - 10.1016/0016-6480(87)90166-3
DO - 10.1016/0016-6480(87)90166-3
M3 - Article
C2 - 3817442
AN - SCOPUS:0023136296
SN - 0016-6480
VL - 65
SP - 199
EP - 202
JO - General and Comparative Endocrinology
JF - General and Comparative Endocrinology
IS - 2
ER -