Effect of edible fungal polysaccharides on improving influenza vaccine protection in mice

Qian Zhang, Minghua Hu, Lu Xu, Xiangliang Yang, Yung Chang, Yanhong Zhu

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Fungal polysaccharides have shown broad spectrum of biological activities, including anti-inflammatory, ant-oxidative and improve immunity. However, oral administration of fungal polysaccharides for rendering the conventional vaccine against influenza virus has been reported rarely. Here, we investigated the potential of fungal polysaccharides in enhancing the influenza vaccine efficacy in a mouse model. Mice were immunized with inactivated H1N1 (A/PR8/1934) influenza vaccine combined with oral polysaccharides lentinan, tremellan, pachymaran and a mixture of the three. The results showed that mice in the polysaccharides/vaccine groups had reduced morbidity, improved viral clearance, and recovered faster than the mice receiving the conventional vaccine only after infection. This effect could be attributed to the increased levels of virus-specific serum antibody IgG and decreased levels of inflammatory cytokine IFN-γ in the lung tissue. Our finding suggests that taking fungal polysaccharides orally might be useful for improving the efficacy of conventional inactive influenza vaccines.

Original languageEnglish (US)
Pages (from-to)981-992
Number of pages12
JournalFood and Agricultural Immunology
Issue number6
StatePublished - Nov 2 2017


  • Lentinan
  • immune
  • influenza virus
  • pachymaran
  • tremellan

ASJC Scopus subject areas

  • Food Science
  • Immunology
  • Agronomy and Crop Science


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