DNA polymerase β inhibitors from Tetracera boiviniana

Ji Ma, Shelley R. Starck, Sidney M. Hecht

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Bioassay-guided fractionation of an active methyl ethyl ketone extract of Tetracera boiviniana, using a sensitive assay to monitor DNA polymerase β inhibition, resulted in the isolation of three known triterpenoids, betulinic acid (1), 3- cis-p-coumaroyl maslinic acid (2), and 3-trans-p-coumaroyl maslinic acid (3). Compounds 1-3 inhibited DNA polymerase β with IC50 values of 14, 15, and 4.2 μM in the presence of bovine serum albumin (BSA) and 6.5, 7.5, and 2.0 μM in the absence of BSA, respectively. Further, compounds 1-3 potentiated the effects of bleomycin in cultured P-388D1 cells.

Original languageEnglish (US)
Pages (from-to)1660-1663
Number of pages4
JournalJournal of Natural Products
Issue number12
StatePublished - Dec 1999
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


Dive into the research topics of 'DNA polymerase β inhibitors from Tetracera boiviniana'. Together they form a unique fingerprint.

Cite this