DNA based arithmetic function: A half adder based on DNA strand displacement

Wei Li, Fei Zhang, Hao Yan, Yan Liu

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Biomolecular programming utilizes the reactions and information stored in biological molecules, such as proteins and nucleic acids, for computational purposes. DNA has proven itself an excellent candidate for building logic operating systems due to its highly predictable molecular behavior. In this work we designed and realized an XOR logic gate and an AND logic gate based on DNA strand displacement reactions. These logic gates utilize ssDNA as input and output signals. The XOR gate and the AND gate were used as building blocks for constructing a half adder logic circuit, which is a primary step in constructing a full adder, a basic arithmetic unit in computing. This work provides the field of DNA molecular programming with a potential universal arithmetic tool.

Original languageEnglish (US)
Pages (from-to)3775-3784
Number of pages10
Issue number6
StatePublished - Feb 14 2016

ASJC Scopus subject areas

  • Materials Science(all)


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