Disposable point-of-use optical biosensor for multiple biomarker detection

Joseph T. Smith; Benjamin A. Katchman; Yong Kyun Lee; Barry P. O'Brien; Edward J. Bawolek; Sahil S. Shah; Jennifer Blain Christen

doi:10.1109/BioCAS.2014.6981714

Disposable point-of-use optical biosensor for multiple biomarker detection

Joseph T. Smith, Benjamin A. Katchman, Yong Kyun Lee, Barry P. O'Brien, Edward J. Bawolek, Sahil S. Shah, Jennifer Blain Christen

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Scopus citations

Abstract

This work explored the viability of a new miniaturized fluorescence measurement-based sensor architecture using organic light emitting diode (OLED) display and photodiode active matrix array technology for point-of-use diagnosis of multiple disease biomarkers in a low cost disposable configuration. Sensor feasibility and optical performance were evaluated using a bright 0.3mW/mm² 2 × 2 mm, 455nm blue OLED emitter test structure configured first with orthogonally crossed linear polarizing film; and second, with band-pass and long-pass optical filters. Preliminary measurement results indicated that this type of sensor architecture requires optical filters to approach the sensitivity of laboratory fluorescence-based instrumentation.

Original language	English (US)
Title of host publication	IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	268-271
Number of pages	4
ISBN (Electronic)	9781479923465
DOIs	https://doi.org/10.1109/BioCAS.2014.6981714
State	Published - Dec 9 2014
Event	10th IEEE Biomedical Circuits and Systems Conference, BioCAS 2014 - Lausanne, Switzerland Duration: Oct 22 2014 → Oct 24 2014

Publication series

Name	IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings

Other

Other	10th IEEE Biomedical Circuits and Systems Conference, BioCAS 2014
Country/Territory	Switzerland
City	Lausanne
Period	10/22/14 → 10/24/14

Keywords

Biomarker
OLED
TFT
Thin-film transistor
active matrix array
biosensor
photodiode
point-of-care

ASJC Scopus subject areas

Hardware and Architecture
Biomedical Engineering

Access to Document

10.1109/BioCAS.2014.6981714

Cite this

Smith, J. T., Katchman, B. A., Lee, Y. K., O'Brien, B. P., Bawolek, E. J., Shah, S. S., & Blain Christen, J. (2014). Disposable point-of-use optical biosensor for multiple biomarker detection. In IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings (pp. 268-271). Article 6981714 (IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BioCAS.2014.6981714

Disposable point-of-use optical biosensor for multiple biomarker detection. / Smith, Joseph T.; Katchman, Benjamin A.; Lee, Yong Kyun et al.
IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2014. p. 268-271 6981714 (IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Smith, JT, Katchman, BA, Lee, YK, O'Brien, BP, Bawolek, EJ, Shah, SS & Blain Christen, J 2014, Disposable point-of-use optical biosensor for multiple biomarker detection. in IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings., 6981714, IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings, Institute of Electrical and Electronics Engineers Inc., pp. 268-271, 10th IEEE Biomedical Circuits and Systems Conference, BioCAS 2014, Lausanne, Switzerland, 10/22/14. https://doi.org/10.1109/BioCAS.2014.6981714

Smith JT, Katchman BA, Lee YK, O'Brien BP, Bawolek EJ, Shah SS et al. Disposable point-of-use optical biosensor for multiple biomarker detection. In IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2014. p. 268-271. 6981714. (IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings). doi: 10.1109/BioCAS.2014.6981714

Smith, Joseph T. ; Katchman, Benjamin A. ; Lee, Yong Kyun et al. / Disposable point-of-use optical biosensor for multiple biomarker detection. IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 268-271 (IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings).

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abstract = "This work explored the viability of a new miniaturized fluorescence measurement-based sensor architecture using organic light emitting diode (OLED) display and photodiode active matrix array technology for point-of-use diagnosis of multiple disease biomarkers in a low cost disposable configuration. Sensor feasibility and optical performance were evaluated using a bright 0.3mW/mm2 2 × 2 mm, 455nm blue OLED emitter test structure configured first with orthogonally crossed linear polarizing film; and second, with band-pass and long-pass optical filters. Preliminary measurement results indicated that this type of sensor architecture requires optical filters to approach the sensitivity of laboratory fluorescence-based instrumentation.",

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Disposable point-of-use optical biosensor for multiple biomarker detection

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Keywords

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