Development of GPIIb/IIIa antagonists as antithrombotic drugs

Andrew J. Nichols; Robert R. Ruffolo; William F. Huffman; George Poste; James Samanen

doi:10.1016/0165-6147(92)90126-Q

Development of GPIIb/IIIa antagonists as antithrombotic drugs

Andrew J. Nichols, Robert R. Ruffolo, William F. Huffman, George Poste, James Samanen

Research output: Contribution to journal › Review article › peer-review

73 Scopus citations

Abstract

Thrombosis represents a major target for development of drugs to prevent and treat a variety of cardiovascular and cerebrovascular diseases, which are the leading cause of morbidity and mortality in the Western world. This review by Andy Nichols and colleagues focuses on a central process in thrombosis, namely platelet aggregation, and how it can be inhibited by antagonists of the adhesion molecule GPIIb/IIIa. Successful and future therapeutic applications of GPIIb/IIIa antagonists, and their pharmacology, are considered in detail.

Original language	English (US)
Pages (from-to)	413-417
Number of pages	5
Journal	Trends in Pharmacological Sciences
Volume	13
Issue number	C
DOIs	https://doi.org/10.1016/0165-6147(92)90126-Q
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Toxicology
Pharmacology

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title = "Development of GPIIb/IIIa antagonists as antithrombotic drugs",

abstract = "Thrombosis represents a major target for development of drugs to prevent and treat a variety of cardiovascular and cerebrovascular diseases, which are the leading cause of morbidity and mortality in the Western world. This review by Andy Nichols and colleagues focuses on a central process in thrombosis, namely platelet aggregation, and how it can be inhibited by antagonists of the adhesion molecule GPIIb/IIIa. Successful and future therapeutic applications of GPIIb/IIIa antagonists, and their pharmacology, are considered in detail.",

author = "Nichols, {Andrew J.} and Ruffolo, {Robert R.} and Huffman, {William F.} and George Poste and James Samanen",

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AU - Nichols, Andrew J.

AU - Ruffolo, Robert R.

AU - Huffman, William F.

AU - Poste, George

AU - Samanen, James

PY - 1992

Y1 - 1992

N2 - Thrombosis represents a major target for development of drugs to prevent and treat a variety of cardiovascular and cerebrovascular diseases, which are the leading cause of morbidity and mortality in the Western world. This review by Andy Nichols and colleagues focuses on a central process in thrombosis, namely platelet aggregation, and how it can be inhibited by antagonists of the adhesion molecule GPIIb/IIIa. Successful and future therapeutic applications of GPIIb/IIIa antagonists, and their pharmacology, are considered in detail.

AB - Thrombosis represents a major target for development of drugs to prevent and treat a variety of cardiovascular and cerebrovascular diseases, which are the leading cause of morbidity and mortality in the Western world. This review by Andy Nichols and colleagues focuses on a central process in thrombosis, namely platelet aggregation, and how it can be inhibited by antagonists of the adhesion molecule GPIIb/IIIa. Successful and future therapeutic applications of GPIIb/IIIa antagonists, and their pharmacology, are considered in detail.

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Development of GPIIb/IIIa antagonists as antithrombotic drugs

Abstract

ASJC Scopus subject areas

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