@article{7d16b4f66e6345b3a754e7c83b546256,
title = "Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis",
abstract = "Deregulated Myc transcriptionally reprograms cell metabolism to promote neoplasia. Here we show that oncogenic Myc requires the Myc superfamily member MondoA, a nutrient-sensing transcription factor, for tumorigenesis. Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc-induced reprogramming of multiple metabolic pathways, resulting in apoptosis. Identification and knockdown of genes coregulated by Myc and MondoA have allowed us to define metabolic functions required by deregulated Myc and demonstrate a critical role for lipid biosynthesis in survival of Myc-driven cancer. Furthermore, overexpression of a subset of Myc and MondoA coregulated genes correlates with poor outcome of patients with diverse cancers. Coregulation of cancer metabolism by Myc and MondoA provides the potential for therapeutics aimed at inhibiting MondoA and its target genes.",
author = "Carroll, {Patrick A.} and Daniel Diolaiti and Lisa McFerrin and Haiwei Gu and Danijel Djukovic and Jianhai Du and Cheng, {Pei Feng} and Sarah Anderson and Michelle Ulrich and Hurley, {James B.} and Daniel Raftery and Ayer, {Donald E.} and Eisenman, {Robert N.}",
note = "Funding Information: We thank Patrick Paddison and Christopher Hubert for providing CB660 derivative cell lines and Carla Grandori for discussions and advice. We are also grateful to David Hockenbery, Fionnuala Morrish, Daciana Margineantu, Brian Iritani, Julita Ramirez, and Paul Shannon for discussions and critical readings of the manuscript. This research was supported by grant R37CA57138 from NIH/NCI (to R.N.E.), an ITHS Clinical and Translational Science Award UL1RR025014 from NIH/NCRR (to R.N.E.), the Chromosome Metabolism and Cancer Training Grant T32 CA009657 (to P.A.C.), RO1 EY06641 and RO1 EY017863 (to J.B.H.), and grant R01-GM055668 from NIH/NIGMS (to D.E.A.). Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = feb,
day = "9",
doi = "10.1016/j.ccell.2014.11.024",
language = "English (US)",
volume = "27",
pages = "271--285",
journal = "Cancer cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "2",
}