TY - JOUR
T1 - Decreased GlycA after lifestyle intervention among obese, prediabetic adolescent Latinos
AU - Olson, Micah L.
AU - Rentería-Mexía, Ana
AU - Connelly, Margery A.
AU - Vega-Lopez, Sonia
AU - Soltero, Erica G.
AU - Konopken, Yolanda P.
AU - Williams, Allison N.
AU - Castro, Felipe
AU - Keller, Colleen S.
AU - Yang, Hongwei P.
AU - Todd, Michael
AU - Shaibi, Gabriel
N1 - Funding Information:
Funding: This research was funded by the National Institutes of Health/National Institute on Minority Health and Health Disparities ( P20MD002316 ; U54MD002316 ). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIMHD or the NIH. Drs Olson, Soltero, and Shaibi were also supported by a grant from the National Institutes of Health,National Institute of Diabetes and Digestive and Kidney Disease ( R01 DK10757901 ).
Publisher Copyright:
© 2018 National Lipid Association
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Obese youth with prediabetes are at increased risk for premature morbidity and mortality through multiple mechanisms, including increased systemic inflammation. GlycA is a novel measure of systemic inflammation that predicts type II diabetes, cardiovascular events, and all-cause mortality in adults. Objective: The purpose of the present study was to examine changes in GlycA after lifestyle intervention among obese, prediabetic Latino youth. Methods: Obese, prediabetic Latino youth (n = 27; 15.5 ± 1.1 years, 13 males/14 females) completed a 12-week lifestyle intervention that included weekly nutrition education and 3 d/wk of moderate to vigorous physical activity. Prediabetes was characterized by an expanded definition of impaired glucose tolerance, using 2-hour glucose ≥120 mg/dL after an oral glucose tolerance test. GlycA was assessed at baseline and 12 weeks using nuclear magnetic resonance spectroscopy. Results: After the lifestyle intervention, GlycA was significantly reduced (445.3 ± 51.3 μmol/L to 419.0 ± 50.0 μmol/L, P =.01) (mean ± standard deviation). Additional improvements were observed in multiple cardiovascular risk factors, including body mass index (BMI; 34.8 ± 5.0 kg/m 2 to 34.0 ± 5.1 kg/m 2 , P <.001), total cholesterol (154.1 ± 30.3 mg/dL to 143.3 ± 29.1 mg/dL, P =.003), and 2-hour glucose (141.0 ± 13.2 mg/dL to 115.9 ± 31.4 mg/dL, P <.001). Decreases in GlycA were associated with decreases in 2-hour glucose (r = 0.49, P =.008) and BMI (r = 0.41, P =.03). Conclusion: These data are consistent with the hypothesis that lifestyle intervention might improve GlycA levels in obese, prediabetic adolescent Latinos, but randomized trial evidence is needed. Healthy lifestyle modifications among high-risk youth may decrease future risk of cardiometabolic disease through reducing systemic inflammation, in addition to improving traditional cardiovascular risk factors.
AB - Background: Obese youth with prediabetes are at increased risk for premature morbidity and mortality through multiple mechanisms, including increased systemic inflammation. GlycA is a novel measure of systemic inflammation that predicts type II diabetes, cardiovascular events, and all-cause mortality in adults. Objective: The purpose of the present study was to examine changes in GlycA after lifestyle intervention among obese, prediabetic Latino youth. Methods: Obese, prediabetic Latino youth (n = 27; 15.5 ± 1.1 years, 13 males/14 females) completed a 12-week lifestyle intervention that included weekly nutrition education and 3 d/wk of moderate to vigorous physical activity. Prediabetes was characterized by an expanded definition of impaired glucose tolerance, using 2-hour glucose ≥120 mg/dL after an oral glucose tolerance test. GlycA was assessed at baseline and 12 weeks using nuclear magnetic resonance spectroscopy. Results: After the lifestyle intervention, GlycA was significantly reduced (445.3 ± 51.3 μmol/L to 419.0 ± 50.0 μmol/L, P =.01) (mean ± standard deviation). Additional improvements were observed in multiple cardiovascular risk factors, including body mass index (BMI; 34.8 ± 5.0 kg/m 2 to 34.0 ± 5.1 kg/m 2 , P <.001), total cholesterol (154.1 ± 30.3 mg/dL to 143.3 ± 29.1 mg/dL, P =.003), and 2-hour glucose (141.0 ± 13.2 mg/dL to 115.9 ± 31.4 mg/dL, P <.001). Decreases in GlycA were associated with decreases in 2-hour glucose (r = 0.49, P =.008) and BMI (r = 0.41, P =.03). Conclusion: These data are consistent with the hypothesis that lifestyle intervention might improve GlycA levels in obese, prediabetic adolescent Latinos, but randomized trial evidence is needed. Healthy lifestyle modifications among high-risk youth may decrease future risk of cardiometabolic disease through reducing systemic inflammation, in addition to improving traditional cardiovascular risk factors.
KW - Cardiovascular disease
KW - Impaired glucose tolerance
KW - Inflammation
KW - Latino
KW - Pediatric obesity
KW - Type II diabetes
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U2 - 10.1016/j.jacl.2018.09.011
DO - 10.1016/j.jacl.2018.09.011
M3 - Article
C2 - 30342918
AN - SCOPUS:85054845189
SN - 1933-2874
VL - 13
SP - 186
EP - 193
JO - Journal of Clinical Lipidology
JF - Journal of Clinical Lipidology
IS - 1
ER -